INT137980

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 36
Disease Relevance 22.49
Pain Relevance 10.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RX7) cytoplasm (P2RX7)
Anatomy Link Frequency
macrophages 4
monocytes 3
liver 2
microglial cells 2
hepatocytes 1
P2RX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 395 99.98 Very High Very High Very High
Glutamate 84 99.80 Very High Very High Very High
Spinal cord 322 99.78 Very High Very High Very High
addiction 71 99.66 Very High Very High Very High
Chronic pancreatitis 6 99.64 Very High Very High Very High
Multiple sclerosis 343 99.54 Very High Very High Very High
Inflammation 490 99.50 Very High Very High Very High
gABA 20 99.40 Very High Very High Very High
Hippocampus 22 98.84 Very High Very High Very High
cytokine 63 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 190 99.68 Very High Very High Very High
Pancreatitis 12 99.64 Very High Very High Very High
Demyelinating Disease 365 99.54 Very High Very High Very High
INFLAMMATION 597 99.50 Very High Very High Very High
Apoptosis 33 99.48 Very High Very High Very High
Hepatitis B Virus Infection 258 99.42 Very High Very High Very High
Hepatitis D Virus Infection 330 99.26 Very High Very High Very High
Death 57 99.24 Very High Very High Very High
Neointima 14 99.00 Very High Very High Very High
Hypoxia 13 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is considered to inhibit calcium mobilization after activation of human P2X7 receptors [19].
Positive_regulation (activation) of P2X7
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 1.79 Pain Relevance 0.04
Chronic activation of P2X7 can produce apoptosis and thus not surprisingly, expression and activation of this receptor is tightly regulated.
Positive_regulation (activation) of P2X7 associated with apoptosis
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.73 Pain Relevance 0.18
Activation is associated with but not limited to [13], [16], [32], [34]: (i) prolonged opening of an ion channel with influx of calcium and sodium ions, (ii) formation of pores in the cell membrane, (iii) activation of caspases, (iv) activation of receptor tyrosine kinases, (v) temporary reorganization of the actin cytoskeleton, (vi) transient membrane blebbing, and (vii) fusion between cells with activated P2X7.
Positive_regulation (activated) of P2X7 in pores
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.33 Pain Relevance 0.03
If the attachment of HDV and HBV to hepatocytes does in fact activate P2X7, even transiently, this could be linked to the knowledge that P2X7 is a regulator of several key inflammatory molecules, including IL-1?
Positive_regulation (activate) of P2X7 in hepatocytes associated with hepatitis d virus infection, inflammation and hepatitis b virus infection
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.79 Pain Relevance 0.11
release and whether this required activation of the P2X7 receptor pathway.
Spec (whether) Positive_regulation (activation) of P2X7
5) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.21
P2X7 mRNA upregulation was associated with chronic pancreatitis, and heightened protein expression was found to be localized to infiltrating cells.
Positive_regulation (upregulation) of P2X7 associated with chronic pancreatitis
6) Confidence 0.61 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.54 Pain Relevance 0.45
In addition, a key role for P2X7 receptors is established as well as possibly contributory roles for P2X2, P2X4, P2X5, P2Y2, P2Y4 and P2Y14 based on agonist preferences [40].
Positive_regulation (role) of P2X7 associated with agonist
7) Confidence 0.49 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0 Pain Relevance 0.18
Monocyte treatment with CL075 for 3 h (without P2X7 receptor secondary stimulation) resulted in a significant release of IL-1?
Neg (without) Positive_regulation (stimulation) of P2X7 in Monocyte
8) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.08
release, we investigated whether prolonged LPS stimulation without P2X7 receptor secondary stimulation could also result in IL-1?
Neg (without) Positive_regulation (stimulation) of P2X7
9) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.09
Conversely, some IL-1-driven inflammatory disease models refute a role for the P2X7 receptor; IL-1-mediated neointima formation is unaltered in P2X7 receptor-deficient mice (54).
Positive_regulation (role) of P2X7 associated with inflammation, neointima and disease
10) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 1.10 Pain Relevance 0.38
The differences in P2X7 receptor activation requirement for IL-1?
Positive_regulation (requirement) of P2X7
11) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.55 Pain Relevance 0.23
Thirdly, it was found that P2X7 receptors are upregulated by 80% in hippocampi of pilocarpine-induced chronic epileptic rats, as shown by fluorimetric, immunohistochemical and Western-blotting techniques [9].
Positive_regulation (upregulated) of P2X7 associated with epilepsy
12) Confidence 0.45 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.72 Pain Relevance 0.19
Furthermore, since P2X7 activation is known to be a major component of inflammatory responses, it is proposed that HDV and HBV attachment to susceptible cells, might also contribute to inflammation in the liver, that is, hepatitis.



Positive_regulation (activation) of P2X7 in liver associated with hepatitis d virus infection, inflammatory response, inflammation, hepatitis b virus infection and hepatitis
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3004961 Disease Relevance 1.51 Pain Relevance 0.10
Inflammation in the liver can also be mediated by P2X7 activation [43].
Positive_regulation (activation) of P2X7 in liver associated with inflammation
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 1.37 Pain Relevance 0.22
from monocytes showed selectivity for specific TLR agonists and was accelerated by P2X7 receptor activation.
Positive_regulation (activation) of P2X7 in monocytes associated with agonist
15) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2906308 Disease Relevance 0.06 Pain Relevance 0.20
in the absence of P2X7 receptor activation, which is not seen in macrophages.
Positive_regulation (activation) of P2X7 in macrophages
16) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.13
in response to brief (3 h) TLR4 ligand priming by LPS and subsequent P2X7 receptor activation and given that circulating monocytes are exposed to a variety of pathogens, we determined whether other TLR agonists prime in an analogous manner.
Positive_regulation (activation) of P2X7 in monocytes associated with agonist
17) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.18
release was independent of P2X7 receptor activation.
Positive_regulation (activation) of P2X7
18) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.11
in response to P2X7 receptor activation, in keeping with previous findings (12, 22).
Positive_regulation (activation) of P2X7
19) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.17 Pain Relevance 0.18
production and release were investigated for dependence upon caspase-1, P2X7 receptor activation, and loss of membrane asymmetry associated with microvesicle shedding.
Positive_regulation (activation) of P2X7 associated with addiction
20) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox