INT138016

Context Info Confidence 0.43 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.28 Pain Relevance 2.96

peptidase activity (Naalad2) cellular_component (Naalad2)

Anatomy Link Frequency brain 1 CNS 1 Naalad2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 47 100.00 Neurotransmitter 10 100.00 neuralgia 5 100.00 excitatory amino acid 5 100.00 Analgesic 3 99.98 Lasting pain 3 98.52 Pain 15 97.60 Central nervous system 4 97.48 antagonist 5 97.20 Migraine 67 95.76

Disease Link Frequency Relevance Heat Pain 18 98.52 Headache 69 95.76 INFLAMMATION 2 91.84 Congenital Anomalies 2 87.20 Stroke 1 85.20 Neuropathic Pain 1 82.48 Migraine Disorders 2 28.08 Depression 2 14.72 Cluster Headache 2 5.00 Cognitive Disorder 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.

Regulation (Effects) of NAAG in brain associated with neuralgia and lasting pain

1) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Title Doc Link 16926034 Disease Relevance 0.18 Pain Relevance 0.44

The analgesic effects of SLx-3095-1, APDC, ZJ-43, 2-PMPA and NAAG were blocked by co-injection of LY341495, a selective group II mGluR antagonist.

Regulation (effects) of NAAG associated with antagonist and analgesic

2) Confidence 0.21 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17241276 Disease Relevance 0.59 Pain Relevance 1.06

The measured changes in these excitatory amino acid neurotransmitters (NAAG) and related species (Gln) provide some insights into altered central nervous system (CNS) mechanisms in migraine and may contribute to abnormal CNS processing including changes during the migraine state (e.g., process of central sensitization [68,69], progressing from acute episodic to chronic/daily migraine [70] or abnormalities during the interictal period [71-74].

Regulation (changes) of NAAG in CNS associated with glutamate, neurotransmitter, central sensitization, congenital anomalies, migraine, central nervous system and excitatory amino acid

3) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714306 Disease Relevance 0.51 Pain Relevance 1.47

General Comments

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