INT138016

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Naalad2) cellular_component (Naalad2)
Anatomy Link Frequency
brain 1
CNS 1
Naalad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 47 100.00 Very High Very High Very High
Neurotransmitter 10 100.00 Very High Very High Very High
neuralgia 5 100.00 Very High Very High Very High
excitatory amino acid 5 100.00 Very High Very High Very High
Analgesic 3 99.98 Very High Very High Very High
Lasting pain 3 98.52 Very High Very High Very High
Pain 15 97.60 Very High Very High Very High
Central nervous system 4 97.48 Very High Very High Very High
antagonist 5 97.20 Very High Very High Very High
Migraine 67 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 18 98.52 Very High Very High Very High
Headache 69 95.76 Very High Very High Very High
INFLAMMATION 2 91.84 High High
Congenital Anomalies 2 87.20 High High
Stroke 1 85.20 High High
Neuropathic Pain 1 82.48 Quite High
Migraine Disorders 2 28.08 Quite Low
Depression 2 14.72 Low Low
Cluster Headache 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.
Regulation (Effects) of NAAG in brain associated with neuralgia and lasting pain
1) Confidence 0.43 Published 2006 Journal Neuropharmacology Section Title Doc Link 16926034 Disease Relevance 0.18 Pain Relevance 0.44
The analgesic effects of SLx-3095-1, APDC, ZJ-43, 2-PMPA and NAAG were blocked by co-injection of LY341495, a selective group II mGluR antagonist.
Regulation (effects) of NAAG associated with antagonist and analgesic
2) Confidence 0.21 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17241276 Disease Relevance 0.59 Pain Relevance 1.06
The measured changes in these excitatory amino acid neurotransmitters (NAAG) and related species (Gln) provide some insights into altered central nervous system (CNS) mechanisms in migraine and may contribute to abnormal CNS processing including changes during the migraine state (e.g., process of central sensitization [68,69], progressing from acute episodic to chronic/daily migraine [70] or abnormalities during the interictal period [71-74].
Regulation (changes) of NAAG in CNS associated with glutamate, neurotransmitter, central sensitization, congenital anomalies, migraine, central nervous system and excitatory amino acid
3) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714306 Disease Relevance 0.51 Pain Relevance 1.47

General Comments

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