INT138021

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.04
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Osm) extracellular region (Osm)
Anatomy Link Frequency
joints 4
dorsal root ganglia 2
Osm (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 2 99.82 Very High Very High Very High
Arthritis 174 99.12 Very High Very High Very High
Inflammation 92 96.00 Very High Very High Very High
chemokine 10 94.32 High High
cytokine 36 93.72 High High
Inflammatory response 8 84.72 Quite High
rheumatoid arthritis 62 83.64 Quite High
Spinal cord 1 46.72 Quite Low
Inflammatory mediators 6 32.84 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 182 99.12 Very High Very High Very High
INFLAMMATION 102 96.00 Very High Very High Very High
Disease 94 91.56 High High
Rheumatoid Arthritis 63 83.64 Quite High
Necrosis 6 75.92 Quite High
Cancer 6 75.56 Quite High
Nociception 1 74.32 Quite High
Severe Combined Immunodeficiency 2 61.80 Quite High
Recurrence 4 42.84 Quite Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.
Positive_regulation (overlap) of Gene_expression (overlap) of oncostatin M in dorsal root ganglia associated with nociceptor
1) Confidence 0.43 Published 2006 Journal Neuroscience Section Title Doc Link 16926070 Disease Relevance 0.07 Pain Relevance 0.29
Overexpression of oncostatin M in the mouse joints induced synovial pathology [61] and anti-oncostatin M treatment suppressed arthritis [62], except in one study in which human oncostatin M treatment was shown to inhibit CAIA [63].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of oncostatin M in joints associated with arthritis
2) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.48 Pain Relevance 0.85
Overexpression of oncostatin M in the mouse joints induced synovial pathology [61] and anti-oncostatin M treatment suppressed arthritis [62], except in one study in which human oncostatin M treatment was shown to inhibit CAIA [63].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of anti-oncostatin M in joints associated with arthritis
3) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.48 Pain Relevance 0.86

General Comments

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