INT138023

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2008
Negated 4
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.05
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Il31ra)
Anatomy Link Frequency
DRGs 5
trigeminal ganglia 2
neurons 1
dermis 1
epithelial cells 1
Il31ra (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 98.40 Very High Very High Very High
cytokine 111 89.60 High High
Inflammation 96 37.28 Quite Low
nociceptor 20 25.00 Low Low
antagonist 34 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 10 100.00 Very High Very High Very High
Nociception 10 96.48 Very High Very High Very High
Asthma 315 78.64 Quite High
Hyperplasia 9 67.44 Quite High
Eosinophilia 19 66.44 Quite High
Targeted Disruption 20 62.64 Quite High
Retinoblastoma 1 53.52 Quite High
INFLAMMATION 103 37.28 Quite Low
Pruritus 1 31.52 Quite Low
Eczema 4 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to reverse-transcriptase polymerase chain reaction, IL-31RA mRNA was detected in the DRGs and trigeminal ganglia, while no expression of IL-31RA mRNA was observed in the CNS.
Neg (no) Gene_expression (expression) of IL-31RA mRNA in trigeminal ganglia
1) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.17 Pain Relevance 0.11
Double immunofluorescence staining revealed IL-31RA to be expressed in a subset of small-sized neurons, all of which colocalized with OSMRbeta.
Gene_expression (expressed) of IL-31RA in neurons
2) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.17 Pain Relevance 0.11
From a northern blot analysis and in situ hybridization histochemistry, IL-31RA mRNA was found to be expressed in the adult DRGs.
Gene_expression (expressed) of IL-31RA mRNA in DRGs
3) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.16 Pain Relevance 0.11
However, little is known about the target cells of IL-31 because it remains unclear which types of cells express IL-31RA.
Gene_expression (express) of IL-31RA
4) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.09 Pain Relevance 0.09
In addition, the expression of IL-31 RA was detected in afferent fibers in the spinal cord and the dermis of the skin.
Gene_expression (expression) of IL-31 RA in dermis associated with rheumatoid arthritis and spinal cord
5) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.18 Pain Relevance 0.11
We also found that the developmental expression pattern of IL-31RA was different from that of OSMRbeta; IL31RA-positive neurons in DRGs first appeared at postnatal day (PN) 10 and reached the adult level at PN14, whereas OSMRbeta-positive neurons were observed at PN0 for the first time.
Gene_expression (expression) of IL-31RA in DRGs
6) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.17 Pain Relevance 0.10
In the present study, we investigated the IL-31RA expression in the adult and developing DRGs.
Spec (investigated) Gene_expression (expression) of IL-31RA in DRGs
7) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.15 Pain Relevance 0.11
According to reverse-transcriptase polymerase chain reaction, IL-31RA mRNA was detected in the DRGs and trigeminal ganglia, while no expression of IL-31RA mRNA was observed in the CNS.
Neg (no) Gene_expression (detected) of IL-31RA mRNA in trigeminal ganglia
8) Confidence 0.57 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.16 Pain Relevance 0.11
According to reverse-transcriptase polymerase chain reaction, IL-31RA mRNA was detected in the DRGs and trigeminal ganglia, while no expression of IL-31RA mRNA was observed in the CNS.
Neg (no) Gene_expression (expression) of IL-31RA mRNA in DRGs
9) Confidence 0.25 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.17 Pain Relevance 0.11
According to reverse-transcriptase polymerase chain reaction, IL-31RA mRNA was detected in the DRGs and trigeminal ganglia, while no expression of IL-31RA mRNA was observed in the CNS.
Neg (no) Gene_expression (detected) of IL-31RA mRNA in DRGs
10) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.16 Pain Relevance 0.11
Lung epithelial cells express high levels of IL-31R?
Gene_expression (express) of IL-31R in epithelial cells
11) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.47 Pain Relevance 0.13

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