INT13803

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Context Info
Confidence 0.07
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 10.41
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PSN1 1
pancreas 1
Panc2 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 41 99.58 Very High Very High Very High
Bile 1 89.48 High High
alcohol 1 59.48 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 95 100.00 Very High Very High Very High
Pancreatitis 63 99.72 Very High Very High Very High
Pancreatic Cancer 28 99.52 Very High Very High Very High
Malignant Neoplastic Disease 26 99.08 Very High Very High Very High
Carcinoma 16 98.80 Very High Very High Very High
Adenocarcinoma 97 98.66 Very High Very High Very High
Viral Infection 10 96.00 Very High Very High Very High
Infection 14 90.44 High High
Biliary Tract Disease 4 86.16 High High
Choledocholithiasis 1 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of tumor-associated glycoprotein (TAG-72) was examined by immunohistochemistry in pancreatic specimens from normal donors, and from patients with chronic pancreatitis and pancreatic cancer, and was compared with expression of CA 19-9 and DU-PAN-2.
Gene_expression (expression) of DU-PAN-2 associated with cancer, pancreatic cancer and chronic pancreatitis
1) Confidence 0.07 Published 1988 Journal Int. J. Cancer Section Abstract Doc Link 3053465 Disease Relevance 0.66 Pain Relevance 0.26
In the normal pancreas, TAG-72 was expressed in fewer ductal and ductular cells than were CA 19-9 (p less than 0.05) and DU-PAN-2 (p less than 0.01 and 0.001 respectively), whereas in chronic pancreatitis all 3 antigens were expressed in ductal cells but only CA 19-9 and DU-PAN-2 in ductular cells (p less than 0.001).
Gene_expression (expressed) of DU-PAN-2 in pancreas associated with chronic pancreatitis
2) Confidence 0.07 Published 1988 Journal Int. J. Cancer Section Abstract Doc Link 3053465 Disease Relevance 0.68 Pain Relevance 0.28
Comparative studies on the expression of tumor-associated glycoprotein (TAG-72), CA 19-9 and DU-PAN-2 in normal, benign and malignant pancreatic tissue.
Gene_expression (expression) of DU-PAN-2 associated with malignant neoplastic disease and cancer
3) Confidence 0.07 Published 1988 Journal Int. J. Cancer Section Title Doc Link 3053465 Disease Relevance 0.70 Pain Relevance 0.24
Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).
Neg (negative) Gene_expression (negative) of Panc2 in PSN1 associated with cancer
4) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.73 Pain Relevance 0
PDAC transduction by serial dilution of Ad-GFP resulted also in higher expression of GFP in lines not expressing MxA (Ger, PT45, Panc1, Panc2, MiaPaCa2) (Figure 5D and 5E).


Gene_expression (expression) of Panc2 associated with adenocarcinoma
5) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.03 Pain Relevance 0
Previous studies have shown that the DU-PAN-2 antigen is elevated in approximately 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (less than 400 U/ml) in 99% of normal subjects.
Gene_expression (elevated) of DU-PAN-2 associated with adenocarcinoma
6) Confidence 0.06 Published 1988 Journal Pancreas Section Abstract Doc Link 3174610 Disease Relevance 0.66 Pain Relevance 0.07
The physiologic implications of elevated DU-PAN-2 serum antigen levels in patients with normal ductal fluid DU-PAN-2 levels are discussed.
Gene_expression (levels) of DU-PAN-2
7) Confidence 0.05 Published 1988 Journal Pancreas Section Abstract Doc Link 3174610 Disease Relevance 1.50 Pain Relevance 0.24
Six percent of patients with chronic pancreatitis and 13% of patients with severe acute pancreatitis had elevated DU-PAN-2 antigen levels in their sera.
Gene_expression (levels) of DU-PAN-2 associated with pancreatitis and chronic pancreatitis
8) Confidence 0.05 Published 1988 Journal Pancreas Section Abstract Doc Link 3174610 Disease Relevance 1.35 Pain Relevance 0.24
The expression of six sialylated carbohydrate antigens (CA19-9, CA-50, SLEX, SLX, DU-PAN-2, ST-439) was examined in malignant and nonmalignant pancreatic tissues using an immunohistochemical method to elucidate the characteristics of these carbohydrate antigens as tumor markers.
Spec (examined) Gene_expression (expression) of DU-PAN-2 associated with malignant neoplastic disease and cancer
9) Confidence 0.05 Published 1991 Journal Pancreas Section Abstract Doc Link 1678888 Disease Relevance 0.46 Pain Relevance 0
Overall, PanIN 1A/1B was present in 68.1%, PanIN 2 in 40.4%, and PanIN 3 in just 2.1%.
Gene_expression (present) of PanIN 2
10) Confidence 0.04 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 12502933 Disease Relevance 1.46 Pain Relevance 0.35
Our results confirmed also the possible p53 independent p21WAF1/CIP1 expression in some PanIN2, PanIN3 lesions and invasive carcinomas.
Spec (possible) Gene_expression (expression) of PanIN2 associated with carcinoma
11) Confidence 0.00 Published 2003 Journal Neoplasma Section Abstract Doc Link 14628083 Disease Relevance 1.18 Pain Relevance 0.30

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