INT138068

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.45
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chn1)
Anatomy Link Frequency
nerve 1
dorsal root ganglion 1
Chn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 23 100.00 Very High Very High Very High
dorsal root ganglion 8 99.60 Very High Very High Very High
Inflammation 6 98.12 Very High Very High Very High
intrathecal 2 94.88 High High
allodynia 1 93.92 High High
Thermal hyperalgesia 1 92.92 High High
IPN 5 90.04 High High
Calcitonin gene-related peptide 1 89.04 High High
Sciatic nerve 1 88.28 High High
Neuropathic pain 1 86.84 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.60 Very High Very High Very High
Nervous System Injury 3 99.44 Very High Very High Very High
INFLAMMATION 4 98.12 Very High Very High Very High
Neuropathic Pain 4 93.92 High High
Hyperalgesia 1 92.92 High High
Inflammatory Pain 5 90.04 High High
Pain 5 85.56 High High
Cancer 1 82.72 Quite High
Necrosis 1 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both NC and ORL1 receptor IR were upregulated 7 days after nerve injury (to 56 and 55%) and inflammation (to 53 and 48%), respectively.
Positive_regulation (upregulated) of NC in nerve associated with nervous system injury, inflammation and orphanin
1) Confidence 0.50 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.50 Pain Relevance 1.37
By using immunohistochemistry in L4 dorsal root ganglion (DRG) neurons, a marked increase of NC and ORL1 receptor immunoreactivity was detected following CFA.
Positive_regulation (increase) of NC in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and orphanin
2) Confidence 0.25 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17387690 Disease Relevance 0.95 Pain Relevance 1.51

General Comments

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