INT138070

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 4.05
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chn1)
Anatomy Link Frequency
dorsal root ganglion 2
afferent neurons 1
Chn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 30 100.00 Very High Very High Very High
dorsal root ganglion 15 99.70 Very High Very High Very High
Pain 18 99.12 Very High Very High Very High
IPN 9 96.12 Very High Very High Very High
Inflammation 15 95.92 Very High Very High Very High
Sciatic nerve 3 94.36 High High
opioid receptor 3 92.96 High High
Neuropathic pain 3 92.92 High High
Root ganglion neuron 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 99.70 Very High Very High Very High
Pain 9 99.12 Very High Very High Very High
Nervous System Injury 9 96.60 Very High Very High Very High
Inflammatory Pain 9 96.12 Very High Very High Very High
INFLAMMATION 6 95.92 Very High Very High Very High
Neuropathic Pain 9 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double labeling with ATF3 revealed expression of NC and ORL1 receptor in intact as well as in injured primary afferent neurons.
Gene_expression (expression) of NC in afferent neurons associated with orphanin
1) Confidence 0.56 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.37 Pain Relevance 1.27
In intact DRG neurons, both NC and ORL1 receptor IR were present in mainly small- and medium-sized neurons, NC IR in 31% and ORL1 receptor IR in 33% of all neuronal profiles.
Gene_expression (present) of NC in DRG associated with dorsal root ganglion and orphanin
2) Confidence 0.56 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.51 Pain Relevance 1.38
Data on the expression of NC and ORL1 receptor in dorsal root ganglion (DRG) neurons and on its modulation after nerve injury and inflammation are controversial.
Gene_expression (expression) of NC in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, inflammation and orphanin
3) Confidence 0.56 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.17 Pain Relevance 1.13

General Comments

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