INT13808

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.18
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
pituitary 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 6 99.72 Very High Very High Very High
Glutamate 5 98.48 Very High Very High Very High
opiate 1 95.24 Very High Very High Very High
methadone 2 77.84 Quite High
Central nervous system 1 73.60 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 59.56 Quite High
Heart Rate Under Development 1 58.52 Quite High
Pressure And Volume Under Development 1 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glutamate N-methyl-D-aspartate (NMDA) receptor blocker MK-801 (300 micrograms/kg iv) attenuated the pressor-tachycardic responses to TRH and the pressor-mesenteric constrictor responses to glutamate.
Negative_regulation (attenuated) of Regulation (responses) of TRH associated with glutamate
1) Confidence 0.43 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1678932 Disease Relevance 0.18 Pain Relevance 0.18
TRH and TSH responses to cold were inhibited after L-EK administration.
Negative_regulation (inhibited) of Regulation (responses) of TRH associated with enkephalin
2) Confidence 0.42 Published 1983 Journal Life Sci. Section Abstract Doc Link 6401835 Disease Relevance 0 Pain Relevance 0.59
The increase of the PRL basal concentration and its decreased pituitary response following TRH were probably related to a change in the tuberoinfundibolar dopaminergic system (TIDA) because of a chronic intake of opiates whereas the impaired function of the dopaminergic system did not alter the thyrotropin pituitary secretion.
Negative_regulation (decreased) of Regulation (response) of TRH in pituitary associated with opiate
3) Confidence 0.20 Published 1987 Journal Drug Alcohol Depend Section Abstract Doc Link 3125030 Disease Relevance 0 Pain Relevance 0.23

General Comments

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