INT138083

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Anatomy Link Frequency
midbrain 2
Drd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 38 100.00 Very High Very High Very High
midbrain 6 98.16 Very High Very High Very High
drug abuse 7 95.64 Very High Very High Very High
Migraine 1 94.52 High High
headache 6 92.24 High High
dopamine receptor 1 82.68 Quite High
Substantia nigra 3 54.16 Quite High
Neurotransmitter 3 6.84 Low Low
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 10 99.48 Very High Very High Very High
Drug Dependence 7 95.64 Very High Very High Very High
Migraine Without Aura 1 95.04 Very High Very High Very High
Headache 1 92.24 High High
Headache Disorders 3 88.96 High High
Schizophrenia 220 69.48 Quite High
Congenital Anomalies 44 50.00 Quite Low
Targeted Disruption 1 30.96 Quite Low
Disease 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allele 4 of DRD4 was significantly overrepresented in patients with MO compared with both controls and CDHDA.
Positive_regulation (overrepresented) of Gene_expression (overrepresented) of DRD4
1) Confidence 0.40 Published 2006 Journal Eur. J. Neurol. Section Abstract Doc Link 16930369 Disease Relevance 1.02 Pain Relevance 0.88
Another study that administered BPA to 5-day-old rats correlated the onset of hyperactivity at 4–5 weeks of age with increased DA D4 receptor expression and reduced DA transporter expression in the midbrain.173 One study of only male mice exposed to BPA prenatally and neonatally did not find changes in DA transporter,174 although a similar study found BPA increased TH and DA transporter immunoreactivity in the limbic area.175
Positive_regulation (increased) of Gene_expression (expression) of DA D4 receptor in midbrain associated with dopamine, midbrain and attention deficit hyperactivity disorder
2) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.32 Pain Relevance 0.67

General Comments

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