INT138095

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.36
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2c) plasma membrane (Grin2c) cytoplasm (Grin2c)
Anatomy Link Frequency
lamina 1
dorsal horn 1
Grin2c (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 23 100.00 Very High Very High Very High
Spinal cord 20 100.00 Very High Very High Very High
Rostral ventromedial medulla 3 99.72 Very High Very High Very High
nMDA receptor 151 99.56 Very High Very High Very High
Dorsal horn neuron 15 98.48 Very High Very High Very High
Periaqueductal grey 2 97.68 Very High Very High Very High
Morphine 7 96.24 Very High Very High Very High
Antinociceptive 3 95.40 Very High Very High Very High
tolerance 3 88.80 High High
tail-flick 1 87.80 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 98.16 Very High Very High Very High
Nociception 2 93.56 High High
Schizophrenia 13 50.00 Quite Low
Disease 11 17.76 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Neuropathic Pain 13 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NR1 and all subunits of NR2 family (NR2A, NR2B, NR2C, NR2D) of NMDA receptor complex was examined using immunoblotting method.
Spec (examined) Gene_expression (expression) of NR2C associated with nmda receptor
1) Confidence 0.63 Published 2007 Journal Drug Alcohol Depend Section Abstract Doc Link 16930867 Disease Relevance 0.36 Pain Relevance 1.40
In addition, more NR2D mRNA is expressed in adult dorsal horn and embryonic spinal cord than NR2C mRNA [5,37,38].
Gene_expression (expressed) of NR2C in dorsal horn associated with dorsal horn and spinal cord
2) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.49
In situ hybridization studies report the distinct existence of NR2A and NR2B subunit mRNA in rodent lamina II [26-28]. mRNA of NR2D, but not NR2C, is also expressed in lamina II [27].
Gene_expression (expressed) of NR2C in lamina
3) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.10
Also, we observed that the two-step procedure unmasked core interacting proteins that were not detected by mass spectrometry in the single-step purification: Ten known PSD-95 interactors, Begain, Cit, Grik2, Grik5, Grin2c, Kcna4, Lrp1, Nlgn2, Nlgn3 and Shank1, were present only after the tandem purification.
Gene_expression (present) of Grin2c
4) Confidence 0.13 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.03

General Comments

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