INT138125

Context Info Confidence 0.49 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.04 Pain Relevance 0.52

cytoplasm (MMP14)

Anatomy Link Frequency skin 1 osteoclast 1 nucleus pulposus 1 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 16 100.00 palliative 45 93.56 backache 1 64.56 TRP channel 1 61.92 cytokine 2 45.36 Pain 10 5.00 Inflammation 4 5.00 Analgesic 3 5.00 imagery 2 5.00 Fibrositis 1 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 70 99.88 Cancer 75 99.84 Metastasis 70 99.64 Hepatocellular Cancer 58 90.64 Injury 33 87.12 Osteolysis 8 86.68 Necrosis 1 84.16 Malignant Neoplastic Disease 2 77.48 Aggression 2 70.32 Lifespan 8 69.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3; p38, JNK, and NF-kappaB regulate the induction of MMP-13; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha.

Positive_regulation (up-regulation) of MT1-MMP in nucleus pulposus

1) Confidence 0.49 Published 2006 Journal Matrix Biol. Section Abstract Doc Link 16934445 Disease Relevance 0.29 Pain Relevance 0.06

The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.

Positive_regulation (activator) of MT1-MMP associated with cancer

2) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.13 Pain Relevance 0.38

We conducted a series of studies to assess the contribution of prostate cancer cell–derived mt1-mmp to bone metastasis.

Positive_regulation (derived) of mt1-mmp associated with prostate cancer and metastasis

3) Confidence 0.14 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.42 Pain Relevance 0

We further showed that mt1-mmp upregulation in cancer cells resulted in the release of one or more factors that promoted osteoclast differentiation in vitro.

Positive_regulation (upregulation) of mt1-mmp in osteoclast associated with cancer

4) Confidence 0.14 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.05 Pain Relevance 0

For wIRA with appropriate therapeutic irradiances and doses it could not only be demonstrated, that it is harmless for human skin (no induction of matrix metalloproteinase 1) [13], [24], but that it has cell protective effects against the damages caused by UV radiation [23], [24], [25].

Positive_regulation (induction) of matrix metalloproteinase 1 in skin associated with metalloproteinase

5) Confidence 0.09 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.16 Pain Relevance 0.08

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