INT138133

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.07

mitochondrion (Nfkb1) Golgi apparatus (Mmp13) DNA binding (Nfkb1) protein complex (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1)

Anatomy Link Frequency nucleus pulposus 2 Nfkb1 (Mus musculus) Mmp13 (Rattus norvegicus)

Pain Link Frequency Relevance Heat backache 1 67.20

Disease Link Frequency Relevance Heat Necrosis 1 86.80 Cancer 1 86.44 Low Back Pain 1 67.20 Intervertebral Disk Degeneration 1 65.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3; p38, JNK, and NF-kappaB regulate the induction of MMP-13; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha.

NF-kappaB Regulation (regulate) of Positive_regulation (induction) of MMP-13 in nucleus pulposus

1) Confidence 0.00 Published 2006 Journal Matrix Biol. Section Abstract Doc Link 16934445 Disease Relevance 0.31 Pain Relevance 0.07

General Comments

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