INT138134

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) peptidase activity (Adamts4)
Nfkb1 (Mus musculus)
Adamts4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 1 56.88 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 76.48 Quite High
Cancer 1 76.12 Quite High
Low Back Pain 1 56.88 Quite High
Intervertebral Disk Degeneration 1 54.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of tissue proteoglycans was mediated by ERK and NF-kappaB-dependent "aggrecanase" activity, suggesting MT1-MMP and ADAMTS-4 and -5 as effectors of TNFalpha-induced tissue catabolism.
NF-kappaB Spec (suggesting) Positive_regulation (dependent) of aggrecanase
1) Confidence 0.01 Published 2006 Journal Matrix Biol. Section Abstract Doc Link 16934445 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

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