INT138141

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.52
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
livers 1
lung 1
MDA-MB-231 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 145 100.00 Very High Very High Very High
palliative 43 98.84 Very High Very High Very High
cytokine 41 97.36 Very High Very High Very High
fibrosis 103 92.76 High High
Inflammation 125 89.76 High High
Inflammatory response 13 82.88 Quite High
pulpitis 1 80.76 Quite High
Bile 5 74.96 Quite High
rheumatoid arthritis 9 50.16 Quite High
cva 1 41.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 244 99.82 Very High Very High Very High
Fibrosis 91 99.64 Very High Very High Very High
Chronic Hepatitis 1 98.48 Very High Very High Very High
Hydronephrosis 77 98.12 Very High Very High Very High
Hepatitis Virus Infection 1 97.76 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 1 96.68 Very High Very High Very High
Cirrhosis 19 95.84 Very High Very High Very High
Injury 110 93.20 High High
Liver Disease 9 92.40 High High
Apoptosis 80 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Transcription (levels) of MMP2 associated with cancer and palliative
1) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.59
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Transcription (expression) of MMP-2 associated with fibrosis
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Our data show a strong upregulation of the mRNA expression of collagenase (MMP1) and both gelatinases (MMP2 and MMP9) compared with controls.
Transcription (expression) of MMP2
3) Confidence 0.39 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.38 Pain Relevance 0.19
However, silica-induced lung MMP2 transcripts were less in CCSP-dnI?
Transcription (transcripts) of MMP2 in lung
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.79 Pain Relevance 0.17
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Transcription (expression) of MMP2 associated with hydronephrosis
5) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.43 Pain Relevance 0.36
Real-time RT-PCR analysis indicated that THL could inhibit the transcription of the MMP-2 and MMP-9 genes in MDA-MB-231 cells (see Additional file 2: Supplemental figure S2).
Transcription (transcription) of MMP-2 in MDA-MB-231 associated with metalloproteinase
6) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.80 Pain Relevance 0.44
Similarly, increased mRNA levels of MMP-9 or MMP-2 have been found in the livers of patients with chronic viral hepatitis as well as nonalcoholic steatohepatitis [104].
Transcription (levels) of MMP-2 in livers associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
7) Confidence 0.12 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.31 Pain Relevance 0.52
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Transcription (expression) of matrix metalloproteinase-2 associated with metalloproteinase
8) Confidence 0.11 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.61 Pain Relevance 0.05
TNF-alpha, IL-1beta, and IL-6 increased the mRNA and/or protein expression of MMP-1, MMP-2, and MMP-3.
Transcription (expression) of MMP-2
9) Confidence 0.05 Published 2006 Journal J Endod Section Abstract Doc Link 16934628 Disease Relevance 0.23 Pain Relevance 0.45
To detect MMP-9 and MMP-2 activity, cell culture medium was collected and concentrated.
Transcription (detect) of MMP-2 associated with metalloproteinase
10) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2988746 Disease Relevance 0.05 Pain Relevance 0.16

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