INT138157
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The purpose of this study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of inducible nitric oxide synthase (iNOS) activity, prostaglandin E(2) (PGE(2)), and metalloproteinase-3 (MMP-3) in experimentally induced inflammation of rat incisors dental pulp. | |||||||||||||||
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and establish an important role for changes in MMP-3 and -9 | |||||||||||||||
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Our laboratory has focused on hippocampal mediated spatial memory and measured elevations in hippocampal MMP-3 and MMP-9 during acquisition of the Morris water | |||||||||||||||
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OBJECTIVE: To evaluate the efficacy and safety of etanercept, a tumor necrosis factor (TNF)-alpha inhibitor, in the treatment of ankylosing spondylitis (AS), and investigate its effect on serum levels of matrix metalloproteinase-3 (MMP-3). | |||||||||||||||
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CONCLUSION: The findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development.
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Interestingly, MMP-3 immunoreactivity was detected within the soma, the nucleus but also as discontinuous staining in dendrites of cultured spinal cord neurons (Fig. 4A). | |||||||||||||||
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Combined effects of ACE and MMP-3 polymorphisms on migraine development. | |||||||||||||||
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Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated. | |||||||||||||||
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Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated. | |||||||||||||||
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Changes in CTX-II and MMP-3 at 12 weeks correlated significantly with changes in BASDAI (r=0.31 and 0.33), and CRP (r=0.40 and 0.43) (p<or=0.005). | |||||||||||||||
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In addition, the effects on matrix metalloproteinase MMP-3 and its antagonist tissue inhibitor of matrix-metalloproteinase 3 (TIMP-1) were determined. | |||||||||||||||
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Since angiotensin-converting enzyme (ACE) and matrix metalloproteinase (MMP) share the same homology, we investigated whether the MMP-3 and ACE I/D gene variants are involved in migraine risk and whether the ACE variant might act in combination with the MMP-3 genetic variant in patients with migraine. | |||||||||||||||
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Serum levels of pro-MMP1, MMP2, MMP3, MMP9, and MMP10 were measured in 199 randomly selected patients from each group. | |||||||||||||||
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TGF-beta1 decreased MMP-1 mRNA expression, while only slightly affecting the MMP-2 and MMP-3 mRNA and/or protein. | |||||||||||||||
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H. pylori infection can up-regulate MMP-3, MMP-7, and MMP-9 in the gastric mucosa and even sera [14-16]. | |||||||||||||||
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If such a regulation between MMP-3 and TIMP-1 play a role in female's ulceration, our data at least imply some other host or environment factors in male should be more dominant than such combined genotype. | |||||||||||||||
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