INT138157

Context Info Confidence 0.54 First Reported 2006 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 12 Total Number 16 Disease Relevance 6.12 Pain Relevance 5.36

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3) proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)

Anatomy Link Frequency microglia 2 nucleus 1 dental pulp 1 Mmp3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 172 100.00 antagonist 1 100.00 Migraine 22 99.84 spinal inflammation 7 99.24 Inflammation 48 98.88 Spinal cord 17 98.64 cytokine 23 98.16 headache 2 97.52 Etanercept 2 97.42 Hippocampus 100 97.04

Disease Link Frequency Relevance Heat Infection 164 100.00 Disease 75 100.00 Headache 22 99.84 Low Back Pain 7 99.24 INFLAMMATION 55 98.88 Primary Headache Disorders 2 97.84 Ulcers 28 97.80 Necrosis 4 97.78 Cancer 2 97.60 Duodenal Ulcer 52 96.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The purpose of this study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of inducible nitric oxide synthase (iNOS) activity, prostaglandin E(2) (PGE(2)), and metalloproteinase-3 (MMP-3) in experimentally induced inflammation of rat incisors dental pulp.

Spec (investigate) Regulation (regulation) of MMP-3 in dental pulp associated with inflammation and metalloproteinase

1) Confidence 0.54 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.27 Pain Relevance 0.22

and establish an important role for changes in MMP-3 and -9

Regulation (changes) of MMP-3 associated with metalloproteinase

2) Confidence 0.37 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0 Pain Relevance 0.50

Our laboratory has focused on hippocampal mediated spatial memory and measured elevations in hippocampal MMP-3 and MMP-9 during acquisition of the Morris water

Regulation (focused) of MMP-3 associated with metalloproteinase

3) Confidence 0.31 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.25 Pain Relevance 0.64

OBJECTIVE: To evaluate the efficacy and safety of etanercept, a tumor necrosis factor (TNF)-alpha inhibitor, in the treatment of ankylosing spondylitis (AS), and investigate its effect on serum levels of matrix metalloproteinase-3 (MMP-3).

Spec (investigate) Regulation (effect) of MMP-3 associated with spinal inflammation, necrosis, cancer, metalloproteinase and etanercept

4) Confidence 0.26 Published 2008 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 18753057 Disease Relevance 0.37 Pain Relevance 0.31

CONCLUSION: The findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development.

Regulation (importance) of MMP-3

5) Confidence 0.23 Published 2009 Journal Ann. Rheum. Dis. Section Body Doc Link 19019896 Disease Relevance 0 Pain Relevance 0

Interestingly, MMP-3 immunoreactivity was detected within the soma, the nucleus but also as discontinuous staining in dendrites of cultured spinal cord neurons (Fig. 4A).

Regulation (immunoreactivity) of MMP-3 in nucleus associated with spinal cord

6) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.17

Combined effects of ACE and MMP-3 polymorphisms on migraine development.

Regulation (effects) of MMP-3 associated with migraine

7) Confidence 0.15 Published 2007 Journal Cephalalgia Section Title Doc Link 17381556 Disease Relevance 0.72 Pain Relevance 1.01

Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.

Regulation (regulated) of MMP-3 in microglia associated with metalloproteinase, disease and infection

8) Confidence 0.10 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.46 Pain Relevance 0.12

Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.

Regulation (regulated) of MMP-3 in microglia associated with metalloproteinase, disease and infection

9) Confidence 0.10 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.64 Pain Relevance 0.16

Changes in CTX-II and MMP-3 at 12 weeks correlated significantly with changes in BASDAI (r=0.31 and 0.33), and CRP (r=0.40 and 0.43) (p<or=0.005).

Regulation (Changes) of MMP-3

10) Confidence 0.09 Published 2008 Journal J. Rheumatol. Section Body Doc Link 18785308 Disease Relevance 0.05 Pain Relevance 0

In addition, the effects on matrix metalloproteinase MMP-3 and its antagonist tissue inhibitor of matrix-metalloproteinase 3 (TIMP-1) were determined.

Regulation (effects) of MMP-3 associated with antagonist and metalloproteinase

11) Confidence 0.09 Published 2007 Journal Curr Med Res Opin Section Abstract Doc Link 17631696 Disease Relevance 0.58 Pain Relevance 0.65

Since angiotensin-converting enzyme (ACE) and matrix metalloproteinase (MMP) share the same homology, we investigated whether the MMP-3 and ACE I/D gene variants are involved in migraine risk and whether the ACE variant might act in combination with the MMP-3 genetic variant in patients with migraine.

Spec (whether) Regulation (involved) of MMP-3 associated with migraine and metalloproteinase

12) Confidence 0.07 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17381556 Disease Relevance 0.59 Pain Relevance 0.90

Serum levels of pro-MMP1, MMP2, MMP3, MMP9, and MMP10 were measured in 199 randomly selected patients from each group.

Regulation (measured) of MMP3

13) Confidence 0.05 Published 2007 Journal Am. Heart J. Section Body Doc Link 18035073 Disease Relevance 0.16 Pain Relevance 0

TGF-beta1 decreased MMP-1 mRNA expression, while only slightly affecting the MMP-2 and MMP-3 mRNA and/or protein.

Regulation (affecting) of MMP-3 mRNA

14) Confidence 0.03 Published 2006 Journal J Endod Section Abstract Doc Link 16934628 Disease Relevance 0.23 Pain Relevance 0.45

H. pylori infection can up-regulate MMP-3, MMP-7, and MMP-9 in the gastric mucosa and even sera [14-16].

Regulation (regulate) of MMP-3 associated with infection

15) Confidence 0.03 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2928200 Disease Relevance 1.26 Pain Relevance 0.22

If such a regulation between MMP-3 and TIMP-1 play a role in female's ulceration, our data at least imply some other host or environment factors in male should be more dominant than such combined genotype.

Regulation (regulation) of MMP-3

16) Confidence 0.03 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2928200 Disease Relevance 0.54 Pain Relevance 0

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