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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.13

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nucleus (HDAC4, Creb1) transcription factor binding (HDAC4, Creb1) nucleoplasm (Creb1)
cytosol (HDAC4) mitochondrion (Creb1) nucleolus (Creb1)
HDAC4 (Homo sapiens)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 65.80 Quite High
orphanin 2 60.80 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the production of ppN/OFQ mRNA is regulated by histone acetylation, also through CREB, as the histone deacetylase (HDAC) inhibitor trichostatin A increases both CREB binding to the promoter and ppN/OFQ mRNA expression.
histone deacetylase Binding (binding) of CREB
1) Confidence 0.03 Published 2006 Journal Gene Section Abstract Doc Link 16935438 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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