INT138195

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC4, Creb1) transcription factor binding (HDAC4, Creb1) nucleoplasm (Creb1)
cytosol (HDAC4) mitochondrion (Creb1) nucleolus (Creb1)
HDAC4 (Homo sapiens)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 65.80 Quite High
orphanin 2 60.80 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the production of ppN/OFQ mRNA is regulated by histone acetylation, also through CREB, as the histone deacetylase (HDAC) inhibitor trichostatin A increases both CREB binding to the promoter and ppN/OFQ mRNA expression.
histone deacetylase Binding (binding) of CREB
1) Confidence 0.03 Published 2006 Journal Gene Section Abstract Doc Link 16935438 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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