INT138209

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 2.07
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
ear 6
trachea 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 32 99.16 Very High Very High Very High
neuropeptide release 12 98.84 Very High Very High Very High
Inflammation 36 97.52 Very High Very High Very High
Somatostatin 16 96.16 Very High Very High Very High
Kinase C 6 95.20 Very High Very High Very High
Calcitonin gene-related peptide 20 91.84 High High
substance P 20 90.12 High High
cytokine 14 64.24 Quite High
Neuropeptide 11 50.00 Quite Low
cINOD 2 36.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 97.52 Very High Very High Very High
Pressure And Volume Under Development 8 96.64 Very High Very High Very High
Neurogenic Inflammation 12 95.36 Very High Very High Very High
Apoptosis 4 79.68 Quite High
Death 18 67.12 Quite High
Encephalitis 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Brain Disease 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin and EFS evoked 27% and more than twofold elevation of PACAP-38 release respectively, compared with the prestimulated basal values from isolated trachea preparation.
Positive_regulation (elevation) of Localization (release) of PACAP-38 in trachea associated with qutenza
1) Confidence 0.41 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.39 Pain Relevance 1.25
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Positive_regulation (activating) of Spec (investigate) Localization (release) of pituitary adenylate cyclase activating polypeptide-38 in ear associated with pressure and volume under development and neuropeptide release
2) Confidence 0.30 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.85
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Positive_regulation (activating) of Spec (investigate) Localization (release) of PACAP-38 in ear associated with pressure and volume under development and neuropeptide release
3) Confidence 0.30 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.85
The aim of the present study was to investigate the release of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and its effects on sensory neuropeptide release in vitro and acute neurogenic ear swelling in vivo.
Spec (investigate) Positive_regulation (activating) of Spec (investigate) Localization (release) of pituitary adenylate cyclase activating polypeptide-38 in ear associated with pressure and volume under development and neuropeptide release
4) Confidence 0.30 Published 2006 Journal Neuroscience Section Abstract Doc Link 16938409 Disease Relevance 0.44 Pain Relevance 0.85
We observed that PACAP increased proliferation of control NPCs, but the effect was not statistically significant in NPCs treated with IFN?
Positive_regulation (increased) of Localization (proliferation) of PACAP
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.36 Pain Relevance 0.27

General Comments

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