INT13822

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 13.79
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
blood 3
platelet 2
salivary gland 2
saliva 2
margin 1
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 16 100.00 Very High Very High Very High
Somatostatin 12 100.00 Very High Very High Very High
Pain 28 99.98 Very High Very High Very High
Calcitonin gene-related peptide 23 99.84 Very High Very High Very High
Nicotine 32 98.84 Very High Very High Very High
cytokine 87 98.56 Very High Very High Very High
metalloproteinase 8 98.24 Very High Very High Very High
cINOD 10 97.48 Very High Very High Very High
Opioid 2 95.68 Very High Very High Very High
anesthesia 12 93.96 High High
Disease Link Frequency Relevance Heat
Pain 30 99.98 Very High Very High Very High
Duodenal Ulcer 4 99.84 Very High Very High Very High
Ulcers 334 99.74 Very High Very High Very High
Stress 148 99.12 Very High Very High Very High
Infection 7 98.64 Very High Very High Very High
Nicotine Addiction 69 98.58 Very High Very High Very High
Disease 37 96.36 Very High Very High Very High
Nociception 44 95.04 Very High Very High Very High
Gastritis 7 94.24 High High
Apoptosis 16 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF, however, did not alter basal or pentagastrin-stimulated pepsin secretion nor did it change mucosal pepsinogen content.
Localization (secretion) of EGF
1) Confidence 0.81 Published 1985 Journal Endocrinology Section Abstract Doc Link 2578037 Disease Relevance 0 Pain Relevance 0.09
Stimulation by theophylline and sildenafil of rat submandibular secretion of protein, epidermal growth factor and flow rate.
Localization (secretion) of epidermal growth factor
2) Confidence 0.80 Published 2003 Journal Pharmacol. Res. Section Title Doc Link 12967588 Disease Relevance 0 Pain Relevance 0.08
Regarding beneficiary effects of increased salivary flow rate and secretion of EGF in maintaining oral health, theophylline and sildenafil may find good places in some oral diseases.
Localization (secretion) of EGF associated with disease
3) Confidence 0.80 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12967588 Disease Relevance 0.10 Pain Relevance 0.06
In the present study, the effects of cAMP- and cGMP-phosphodiesterase (PDE) inhibitors, theophylline, and sildenafil on secretion of protein, amylase and epidermal growth factor (EGF) and the flow rate from rat submandibular saliva were examined in an acute experiment.
Localization (secretion) of epidermal growth factor in saliva
4) Confidence 0.80 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12967588 Disease Relevance 0 Pain Relevance 0.07
In the present study, the effects of cAMP- and cGMP-phosphodiesterase (PDE) inhibitors, theophylline, and sildenafil on secretion of protein, amylase and epidermal growth factor (EGF) and the flow rate from rat submandibular saliva were examined in an acute experiment.
Localization (secretion) of EGF in saliva
5) Confidence 0.80 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12967588 Disease Relevance 0 Pain Relevance 0.07
In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion.
Localization (hypersecretion) of EGF
6) Confidence 0.75 Published 1991 Journal Life Sci. Section Abstract Doc Link 1990233 Disease Relevance 0 Pain Relevance 0.46
In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion.
Localization (hypersecretion) of epidermal growth factor
7) Confidence 0.75 Published 1991 Journal Life Sci. Section Abstract Doc Link 1990233 Disease Relevance 0 Pain Relevance 0.47
[Effect of exogenous administration of platelet-derived growth factor and epidermal growth factor on duodenal ulcer healing in rats treated with indomethacin].
Localization (administration) of epidermal growth factor in platelet associated with duodenal ulcer
8) Confidence 0.69 Published 2002 Journal Gastroenterol Hepatol Section Title Doc Link 11985799 Disease Relevance 0.10 Pain Relevance 0.19
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Localization (secretion) of EGF in salivary gland associated with nicotine addiction and nicotine
9) Confidence 0.67 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.37 Pain Relevance 0.51
Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP).
Localization (release) of EGF in afferent neurons associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.64 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292598 Disease Relevance 0 Pain Relevance 0.34
A new cell lineage can be observed at the ulcer margin that secretes EGF and TFF, so called ulcer associated cell lineage (UACL) [13, 29].
Localization (secretes) of EGF in margin associated with ulcers
11) Confidence 0.63 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.69 Pain Relevance 0
The fall of EGF secretion from tissue cultures of ulcerous patients could be the consequence of endocrine cellular loss or damage, rather than the cause of ulceration.
Localization (secretion) of EGF
12) Confidence 0.63 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1679287 Disease Relevance 0.15 Pain Relevance 0.20
Epidermal growth factor (EGF) and somatostatin released in the culture medium were determined by radioimmunoassay.
Localization (released) of EGF associated with somatostatin
13) Confidence 0.63 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1679287 Disease Relevance 0.15 Pain Relevance 0.21
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Localization (secretion) of EGF in salivary gland associated with nicotine addiction and nicotine
14) Confidence 0.62 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.42 Pain Relevance 0.51
EGF activates cytoplasmic FAK-dependent KOR translation
Localization (translation) of EGF
15) Confidence 0.61 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
, the levels of EGF and/or TGF-?
Localization (/) of EGF
16) Confidence 0.59 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.85 Pain Relevance 0
, EGF, trefoil peptide (pS2/TFF1), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) were measured.


Localization (measured) of EGF in platelet
17) Confidence 0.59 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.30 Pain Relevance 0
Further signalling pathway outputs are highly stimulus dependent, even though it might involve similar components such as receptor tyrosine kinases like in the case of EGF, NGF and GDNF.
Localization (case) of EGF
18) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.57 Pain Relevance 0.47
This technique opens the door to elucidate the influence of other growth factors on Erk1/2, which are so far not described in the context of pain sensitization like EGF.
Localization (sensitization) of EGF associated with pain
19) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.20 Pain Relevance 0.10
Gliospheres were treated with physiologically relevant concentrations of EGF, LIF and TGFß1 either alone or in combination and Western blots were performed for GFAP, Zebrin II and glutamine synthetase (GS) as indices of astrocyte generation.
Localization (concentrations) of EGF in astrocyte
20) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.04

General Comments

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