INT13823

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 97
Total Number 107
Disease Relevance 39.99
Pain Relevance 12.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
neurons 5
nerve 4
uterine 3
lactotrophs 2
submaxillary gland 2
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 516 100.00 Very High Very High Very High
Somatostatin 145 100.00 Very High Very High Very High
Hyperalgesia 126 100.00 Very High Very High Very High
Dismenorea 9 99.96 Very High Very High Very High
cytokine 598 99.88 Very High Very High Very High
agonist 410 99.84 Very High Very High Very High
Arthritis 228 99.60 Very High Very High Very High
peptic ulcer disease 25 99.28 Very High Very High Very High
metalloproteinase 139 98.64 Very High Very High Very High
Inflammation 652 98.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 356 100.00 Very High Very High Very High
Hyperalgesia 126 100.00 Very High Very High Very High
Pancreatic Cancer 19 100.00 Very High Very High Very High
Dysmenorrhea 9 99.96 Very High Very High Very High
Salivary Gland Disease 42 99.84 Very High Very High Very High
Nociception 198 99.82 Very High Very High Very High
Pituitary Cancer 176 99.80 Very High Very High Very High
Rheumatoid Arthritis 247 99.76 Very High Very High Very High
Disorders Of The Lacrimal System 21 99.76 Very High Very High Very High
Seronegative Spondarthritis 192 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epidermal growth factor (EGF) produces uterine contractions in tissues removed from immature and adult rats.
Gene_expression (produces) of EGF in uterine associated with dismenorea
1) Confidence 0.78 Published 1987 Journal FASEB J. Section Abstract Doc Link 3497834 Disease Relevance 0.10 Pain Relevance 0.10
Epidermal growth factor (EGF) produces uterine contractions in tissues removed from immature and adult rats.
Gene_expression (produces) of Epidermal growth factor in uterine associated with dismenorea
2) Confidence 0.78 Published 1987 Journal FASEB J. Section Abstract Doc Link 3497834 Disease Relevance 0.10 Pain Relevance 0.10
Epidermal growth factor (EGF) is produced in Brunner's glands and plays a role in healing and repair of duodenal ulcers.
Gene_expression (produced) of EGF in Brunner's glands associated with duodenal ulcer
3) Confidence 0.78 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11254505 Disease Relevance 0.10 Pain Relevance 0.09
Epidermal growth factor (EGF) is produced in Brunner's glands and plays a role in healing and repair of duodenal ulcers.
Gene_expression (produced) of Epidermal growth factor in Brunner's glands associated with duodenal ulcer
4) Confidence 0.78 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11254505 Disease Relevance 0.10 Pain Relevance 0.09
It is concluded that stimulation of EGF expression in salivary glands and serum may be one of the mechanisms by which capsaicin sensitive nerves contribute to the gastroprotective and ulcer healing actions in the stomach.
Gene_expression (expression) of EGF in nerves associated with qutenza, salivary gland disease and ulcers
5) Confidence 0.78 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.92 Pain Relevance 0.59
In this study, the effects of denervation of sensory neurons with capsaicin (100 mg/kg, s.c.) on acetic acid-induced chronic gastric ulcers and their relationship with the EGF expression in salivary glands, serum and gastric mucosa were investigated.
Gene_expression (expression) of EGF in salivary glands associated with qutenza, salivary gland disease and peptic ulcer
6) Confidence 0.78 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.84 Pain Relevance 0.60
This was accompanied by progressive increase in the GBF and an increase in expression of EGF mRNA in gastric mucosa, as detected by RT-PCR.
Gene_expression (expression) of EGF mRNA
7) Confidence 0.77 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.77 Pain Relevance 0.43
These studies demonstrated unique properties of rebamipide and convincingly showed that it increases gastric mucus glycoprotein components, stimulates migration and proliferation of wounded epithelial cell monolayers, increases expression of epidermal growth factor and its receptor in normal and ulcerated gastric mucosa, and scavenges active oxygen radicals.
Gene_expression (expression) of epidermal growth factor in epithelial cell
8) Confidence 0.74 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753220 Disease Relevance 1.18 Pain Relevance 0.31
EGF produces both an increase in resting tone and the development of rhythmic contractions, and this effect is abolished by treatment with antibodies against EGF.
Gene_expression (produces) of EGF
9) Confidence 0.68 Published 1987 Journal FASEB J. Section Abstract Doc Link 3497834 Disease Relevance 0.10 Pain Relevance 0.10
EGF-like immunofluorescence (EGF-LI) was shown to be present both in the lacrimal glands (extra- and intraorbital) and in the submaxillary gland.
Gene_expression (present) of EGF in submaxillary gland associated with disorders of the lacrimal system
10) Confidence 0.68 Published 1990 Journal Acta Ophthalmol (Copenh) Section Abstract Doc Link 2220366 Disease Relevance 0.53 Pain Relevance 0.09
EGF-like immunofluorescence (EGF-LI) was shown to be present both in the lacrimal glands (extra- and intraorbital) and in the submaxillary gland.
Gene_expression (present) of EGF in submaxillary gland associated with disorders of the lacrimal system
11) Confidence 0.68 Published 1990 Journal Acta Ophthalmol (Copenh) Section Abstract Doc Link 2220366 Disease Relevance 0.53 Pain Relevance 0.10
RESULTS: Salivary EGF levels were not different between both groups of subjects (4.2 +/- 0.34 vs. 5 +/- 0.54 ng/mg protein, NS), and HPLC revealed that salivary EGF in both groups had similar molecular weights.
Gene_expression (levels) of EGF
12) Confidence 0.65 Published 2001 Journal Nephron Section Body Doc Link 11244307 Disease Relevance 0.18 Pain Relevance 0
METHODS: Salivary EGF levels and bioactivities were assayed in 47 maintenance HD patients and 30 normal controls, and the molecular weights of EGF were assessed using high-performance liquid chromatography (HPLC).
Gene_expression (levels) of EGF
13) Confidence 0.65 Published 2001 Journal Nephron Section Body Doc Link 11244307 Disease Relevance 0.20 Pain Relevance 0
Moreover, the EGF-producing cells around the lesion in ulcerous patients seems to be hyperactive, and this hyperfunction of EGF-producing cells might contribute to the in vivo repair of tissue damage.
Gene_expression (producing) of EGF
14) Confidence 0.61 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1679287 Disease Relevance 0.15 Pain Relevance 0.18
Moreover, the EGF-producing cells around the lesion in ulcerous patients seems to be hyperactive, and this hyperfunction of EGF-producing cells might contribute to the in vivo repair of tissue damage.
Gene_expression (producing) of EGF
15) Confidence 0.61 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1679287 Disease Relevance 0.15 Pain Relevance 0.19
The results strongly support the idea that the lacrimal gland is a source of EGF in tear fluid (TF).
Gene_expression (source) of EGF in tear associated with disorders of the lacrimal system
16) Confidence 0.60 Published 1990 Journal Acta Ophthalmol (Copenh) Section Abstract Doc Link 2220366 Disease Relevance 0.60 Pain Relevance 0.07
Administration of EGF was able to: (i) reduce cyclooxygenase expression in the uterus (determined by western blot analysis) and production of prostaglandins by the uterus (evaluated by conversion of [(14)C]arachidonate to labelled prostaglandins); (ii) decrease prostaglandin concentrations in amniotic fluid (radioimmunoassay); (iii) increase NO production (evaluated by conversion of [(14)C]arginine into [(14)C]citrulline); (iv) increase serum progesterone concentrations to more than control concentrations (P<0.05; radioimmunoassay); and (v) reduce the amplitude of the uterine contractions.
Gene_expression (expression) of EGF in uterine associated with dismenorea
17) Confidence 0.60 Published 2003 Journal Reproduction Section Abstract Doc Link 14525528 Disease Relevance 0.16 Pain Relevance 0.16
Removal of salivary glands, which reduced luminal content of EGF and DNA synthesis by about fourfold compared to rats with intact glands, produced a significant delay in healing, and this was further aggravated by capsaicin denervation.
Gene_expression (synthesis) of EGF in salivary glands associated with qutenza and salivary gland disease
18) Confidence 0.60 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.80 Pain Relevance 0.41
CONCLUSION: Nocloprost is superior to ranitidine in the treatment of chronic gastric ulcers, and these effects could be due, at least in part, to higher expression and mucosal content of EGF in the ulcer area.


Gene_expression (expression) of EGF in superior
19) Confidence 0.54 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9361169 Disease Relevance 0 Pain Relevance 0
Thus, only EGF markers rs11568943 and rs2237051 were considered for haplotyping.
Gene_expression (markers) of EGF
20) Confidence 0.54 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1781940 Disease Relevance 0.68 Pain Relevance 0.21

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