INT138235

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.66
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pycard) extracellular region (Pycard) protein complex (Pycard)
cytoplasm (Pycard)
Anatomy Link Frequency
capillary 1
dorsal horn 1
Pycard (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 3 97.64 Very High Very High Very High
Inflammation 10 87.88 High High
Spinal cord 4 87.36 High High
fibrosis 6 83.84 Quite High
intrathecal 1 77.44 Quite High
cytokine 2 76.60 Quite High
Hyperalgesia 1 71.44 Quite High
antagonist 1 57.52 Quite High
Thoracotomy 6 8.64 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 100.00 Very High Very High Very High
Myocardial Infarction 108 98.88 Very High Very High Very High
Cicatrix 12 98.00 Very High Very High Very High
Infarction 18 91.08 High High
Myelitis 3 87.88 High High
Nociception 3 85.76 High High
Fibrosis 6 83.84 Quite High
Nervous System Injury 1 81.56 Quite High
INFLAMMATION 4 76.20 Quite High
Hyperalgesia 1 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS superfusion also induced rapid secretion of active caspase 1 and apoptosis-associated speck-like protein containing a caspase recruitment domain from the isolated dorsal horn.
Positive_regulation (induced) of apoptosis-associated speck-like protein in dorsal horn associated with dorsal horn and apoptosis
1) Confidence 0.33 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.66 Pain Relevance 0.58
In groups NT, M, F, C and ASC/M, the perimeter of the LV was significantly increased compared to the Sham group (33.5±0.2; 34.0±1.1; 33.1±0.8; 32.4±0.5 and 31.5±0.6 mm for NT, M, F, C and ASC/M respectively vs. 27.4±0.2 mm for Sham; P<0.05) as a consequence of the negative remodeling effect of the infarct (figure 3B).
Positive_regulation (increased) of ASC
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919414 Disease Relevance 0.61 Pain Relevance 0
In addition, our data also revealed both an increase in capillary density among the ASC-treated groups and a tendency for an increase in scar wall thickness.
Positive_regulation (increase) of ASC in capillary associated with cicatrix
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919414 Disease Relevance 0.31 Pain Relevance 0.04
As expected, both biopolymers significantly increased ASC cardiac cell retention compared to culture medium (figure 2A).
Positive_regulation (increased) of ASC
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919414 Disease Relevance 0.09 Pain Relevance 0

General Comments

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