INT138236

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
dorsal horn 2
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 3 95.88 Very High Very High Very High
Inflammation 7 87.88 High High
Spinal cord 4 87.36 High High
cytokine 2 76.60 Quite High
intrathecal 1 73.92 Quite High
Hyperalgesia 1 67.92 Quite High
antagonist 1 54.00 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 1 99.80 Very High Very High Very High
Syndrome 2 93.68 High High
Myelitis 3 87.88 High High
Nociception 3 85.76 High High
Nervous System Injury 1 81.56 Quite High
INFLAMMATION 1 76.20 Quite High
Hyperalgesia 1 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS superfusion also induced rapid secretion of active caspase 1 and apoptosis-associated speck-like protein containing a caspase recruitment domain from the isolated dorsal horn.
Positive_regulation (induced) of Localization (secretion) of caspase 1 in dorsal horn associated with dorsal horn and apoptosis
1) Confidence 0.48 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.65 Pain Relevance 0.54
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (triggers) of Localization (release) of caspase 1
2) Confidence 0.03 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0

General Comments

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