INT138255

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.20
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
GABAergic neurons 3
leukocytes 1
neurons 1
Ps (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 188 99.98 Very High Very High Very High
Inflammatory mediators 2 99.90 Very High Very High Very High
Cannabinoid 3 99.58 Very High Very High Very High
Opioid 2 99.20 Very High Very High Very High
Locus ceruleus 32 98.64 Very High Very High Very High
antagonist 10 98.50 Very High Very High Very High
Cannabinoid receptor 1 98.26 Very High Very High Very High
opioid receptor 1 97.50 Very High Very High Very High
qutenza 10 95.64 Very High Very High Very High
Inflammatory response 14 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 100.00 Very High Very High Very High
INFLAMMATION 61 99.70 Very High Very High Very High
Neurodegenerative Disease 5 98.96 Very High Very High Very High
Nociception 3 93.44 High High
Generalized Anxiety Disorder 152 90.36 High High
Disease 144 86.64 High High
Death 4 84.68 Quite High
Sleep Disorders 32 83.96 Quite High
Ganglion Cysts 1 70.88 Quite High
Brain Disease 4 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beginning at 6 months of age, and coinciding with the neurodegenerative process, leukocytes and inflammatory mediators are elevated in serum of mutant PS1/PS2 conditional double knockout (PS cDKO) mice (Jiang et al., 2009).
Positive_regulation (elevated) of PS in leukocytes associated with targeted disruption, inflammatory mediators and neurodegenerative disease
1) Confidence 0.09 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.20 Pain Relevance 0.18
Moreover, PS inhibition of the capsaicin-induced nocifensive response was not significantly reduced by a nonselective opioid receptor antagonist or by cannabinoid receptor antagonists, indicating that neither an opioid- nor a cannabinoid-dependent mechanism mediated the effect of PS.
Neg (neither) Positive_regulation (mediated) of PS associated with cannabinoid receptor, qutenza, cannabinoid, antagonist, opioid receptor and opioid
2) Confidence 0.08 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16945330 Disease Relevance 0.32 Pain Relevance 1.34
Taken together these studies strongly support PS as catalytic subunit of ?
Positive_regulation (support) of PS
3) Confidence 0.06 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.56 Pain Relevance 0
However, since Mus injection in the vlPAG/dDpMe region inhibits at the same time the PS-off and PS-on GABAergic neurons localized in this area and nevertheless induces an increase of PS quantities, it might be concluded that the activation of the vlPAG PS-on GABAergic neurons is not essential to obtain PS.
Positive_regulation (activation) of PS-on in GABAergic neurons associated with gabaergic
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.06 Pain Relevance 0.61
It is likely that these GABAergic neurons form two distinct populations of PS-off and PS-on neurons, respectively.
Positive_regulation (populations) of PS-off in GABAergic neurons associated with gabaergic
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.46 Pain Relevance 0.26
Based on these previous and the present results, we propose that the PS-on GABAergic neurons localized in the vlPAG inhibit during PS the DRN serotonergic and LC noradrenergic neurons and the co-distributed vlPAG/dDpMe GABAergic PS-off neurons inducing by this way the desinhibition of the SLD PS-on neurons.
Positive_regulation (inducing) of PS-off in neurons associated with locus ceruleus and gabaergic
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.13 Pain Relevance 0.49
It is likely that these GABAergic neurons form two distinct populations of PS-off and PS-on neurons, respectively.
Positive_regulation (populations) of PS-on in GABAergic neurons associated with gabaergic
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.46 Pain Relevance 0.27

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