INT13826

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.19
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dbp)
Anatomy Link Frequency
blood 2
BAT 1
Dbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 5 99.98 Very High Very High Very High
fibrosis 73 99.80 Very High Very High Very High
headache 1 75.28 Quite High
agonist 3 75.00 Quite High
beta blocker 1 75.00 Quite High
Cannabinoid receptor 3 50.00 Quite Low
anesthesia 2 25.00 Low Low
depression 1 25.00 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 11 100.00 Very High Very High Very High
Cystic Fibrosis 73 99.80 Very High Very High Very High
Disease 4 93.88 High High
Body Weight 1 82.48 Quite High
Hypertension 2 77.76 Quite High
Pressure Volume 2 Under Development 2 76.88 Quite High
Headache 1 75.28 Quite High
Chronic Disease 2 75.00 Quite High
Stress 1 75.00 Quite High
Increased Venous Pressure Under Development 1 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KEY RESULTS: In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR.
Positive_regulation (caused) of Negative_regulation (decrease) of DBP
1) Confidence 0.42 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20105178 Disease Relevance 0.08 Pain Relevance 0
Isoproterenol at doses of 0.01-1 microgram/kg (i.v.) dose-dependently increased HR and BAT blood flow and decreased DBP.
Positive_regulation (increased) of Negative_regulation (decreased) of DBP in BAT associated with obesity
2) Confidence 0.41 Published 1994 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7982286 Disease Relevance 0.79 Pain Relevance 0.11
Clonidine induced sharp, marked reductions of NE, CRT and DBP, plus a sudden increase of GH, in all the patients during exacerbation periods.
Positive_regulation (induced) of Negative_regulation (reductions) of DBP associated with clonidine
3) Confidence 0.06 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3602260 Disease Relevance 0.24 Pain Relevance 0.26
Both treatments induced a similar significant reduction in systolic blood pressure (SBP) and DBP, allowing normalization of BP in 58% of subjects on cadralazine and 55% on prazosin.
Positive_regulation (induced) of Negative_regulation (reduction) of DBP in blood
4) Confidence 0.05 Published 1991 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 1679390 Disease Relevance 0.46 Pain Relevance 0.11
Decreased storage of both produced and consumed vitamin D may also be due to decreased levels of vitamin D binding protein (DBP) in CF patients, a phenomenon known to exist for 3 decades [26].
Positive_regulation (due) of Negative_regulation (decreased) of DBP associated with fibrosis
5) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817861 Disease Relevance 0.62 Pain Relevance 0.26

General Comments

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