INT138286

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.93
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 2
stem cell 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 77 100.00 Very High Very High Very High
antagonist 12 99.70 Very High Very High Very High
Kinase C 62 99.64 Very High Very High Very High
Opioid 14 99.48 Very High Very High Very High
narcan 1 99.26 Very High Very High Very High
Glutamate 13 96.08 Very High Very High Very High
Dopamine 115 95.92 Very High Very High Very High
Serotonin 3 95.52 Very High Very High Very High
Inflammation 87 95.32 Very High Very High Very High
cINOD 5 94.56 High High
Disease Link Frequency Relevance Heat
Toxicity 22 99.76 Very High Very High Very High
Apoptosis 232 99.74 Very High Very High Very High
Reprotox - General 1 35 99.66 Very High Very High Very High
Disease 258 98.88 Very High Very High Very High
Cancer 148 96.32 Very High Very High Very High
Muscular Atrophy 2 95.88 Very High Very High Very High
INFLAMMATION 112 95.32 Very High Very High Very High
Dwarfism 1 93.80 High High
Stress 65 91.12 High High
Death 91 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, activation of Akt in response to insulin stimulation has been shown to involve the phosphorylation of Ser473 and Thr308 residues (Toker and Newton 2000).
Regulation (involve) of Positive_regulation (activation) of Akt
1) Confidence 0.45 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.27 Pain Relevance 0
Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.
Regulation (regulates) of Positive_regulation (activation) of AKT in stem cell associated with reprotox - general 1
2) Confidence 0.33 Published 2006 Journal Biochem. Pharmacol. Section Title Doc Link 16949054 Disease Relevance 0.64 Pain Relevance 0.21
Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?
Regulation (while) of Positive_regulation (activation) of PKB in muscle
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.27 Pain Relevance 0
These pathways also affect the activities of kinases such as PKC, GSK-3?
Regulation (affect) of Positive_regulation (activities) of kinases associated with kinase c
4) Confidence 0.22 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.52 Pain Relevance 0.08
Besides the inhibitory control on the activation of the Akt pathway, PTEN interacts with molecular substrates directly involved in neurotransmission such as glutamate and serotonin receptors [13], [14].
Regulation (control) of Positive_regulation (activation) of Akt associated with glutamate and serotonin
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.44 Pain Relevance 0.61
Naloxone, an opioid antagonist, inhibits the effects of morphine on Akt-nNOS activation, indicating the involvement of MORs (not shown).


Regulation (effects) of Positive_regulation (activation) of Akt associated with antagonist, narcan, opioid and morphine
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.96
The rapid stimulation of SphK1 was dependent on activation of the PI3K/Akt signaling, which has been shown to mediate the rapid effects of androgens [39], [40].
Regulation (dependent) of Positive_regulation (activation) of Akt
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
2 is activated by CCL21 and modulates Rac activation.
Regulation (modulates) of Positive_regulation (activation) of Rac
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2811739 Disease Relevance 0.54 Pain Relevance 0.27
In essence, this present study provides a comprehensive investigation on the effect of Akt inactivation, Gsk3?
Regulation (effect) of Positive_regulation (inactivation) of Akt
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Blocking of Akt phosphorylation by the PI3K inhibitor Wortmanin indicated that Hsp70 expression is dependent on activated Akt.
Regulation (dependent) of Positive_regulation (activated) of Akt
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Recently, it was shown that Apoptin-induced apoptosis essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 [32].
Regulation (depends) of Positive_regulation (activation) of Akt associated with apoptosis
11) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.84 Pain Relevance 0
toxicity [199] by a mechanism involving Akt and GSK-3?
Regulation (mechanism) of Positive_regulation (involving) of Akt associated with toxicity
12) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.20 Pain Relevance 0
Chemotaxis in a variety of cell types is regulated by local activation of Rac or Ras, and subsequent establishment of a phosphoinositide gradient by phosphatidylinositol 3'-kinase (PI3K) is also important [37,38].
Regulation (regulated) of Positive_regulation (activation) of Rac
13) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.15 Pain Relevance 0.07
The PI3K inhibitors wortmannin and Ly294002 were used to determine whether elevated AKT activity was responsible for the decreased phospho-p38 levels in CD14?
Spec (whether) Regulation (responsible) of Spec (whether) Positive_regulation (responsible) of AKT
14) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.06 Pain Relevance 0.03

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