INT138319

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2009
Negated 4
Speculated 3
Reported most in Body
Documents 3
Total Number 47
Disease Relevance 2.75
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Anatomy Link Frequency
neuronal 2
climbing fiber 1
inhibitory interneurons 1
extracellular matrix 1
interneurons 1
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 405 99.80 Very High Very High Very High
interneuron 45 96.68 Very High Very High Very High
antagonist 48 96.36 Very High Very High Very High
long-term potentiation 180 95.24 Very High Very High Very High
gABA 495 94.72 High High
imagery 225 90.48 High High
GABAergic 45 89.92 High High
Dopamine 45 87.68 High High
Pyramidal cell 45 86.64 High High
Locus ceruleus 1 79.04 Quite High
Disease Link Frequency Relevance Heat
Depression 405 99.80 Very High Very High Very High
Adhesions 90 98.14 Very High Very High Very High
Cockayne Syndrome 10 50.00 Quite Low
Targeted Disruption 1 34.72 Quite Low
Genomic Instability 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Premature Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, RP induction might be regulated through spatio-temporally integrating multiple synaptic inputs from inhibitory interneurons, a climbing fiber, and parallel fibers, and signals arising from cell-adhesion molecules.
Positive_regulation (induction) of RP in inhibitory interneurons associated with adhesions
1) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.18 Pain Relevance 0.10
A cell-adhesion molecule, integrin, a receptor for extracellular matrix proteins, also negatively regulates RP induction through the Src-family of protein tyrosine kinases (Kawaguchi and Hirano, 2006).
Positive_regulation (induction) of RP in extracellular matrix associated with adhesions
2) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.18 Pain Relevance 0.11
Thus, the induction of RP depends predominantly on the intensity rather than the duration of [Ca2+]i increase, whereas its suppression depends more strongly on the duration than on the intensity of GABABR activation.
Positive_regulation (induction) of RP
3) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Taken together, the findings show that RP was induced in an all-or-none manner dependent on the [Ca2+]i increase (at least >0.45 ?
Positive_regulation (induced) of RP
4) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.07
Thus, we confirmed our earlier observation that RP is induced by a large [Ca2+]i increase depending on the CaMKII and PKA activities.
Positive_regulation (induced) of RP
5) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.08
Using these conditioning stimulations, we examined the [Ca2+]i threshold for RP induction.
Spec (examined) Positive_regulation (induction) of RP
6) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.11
M), did not affect the threshold for the RP induction (500 ms, 168±6%; 100 ms, 105±9%; 60 ms, 109±3%; 40 ms, 100±9%; 20 ms, 108±20%) (Figure 8E).
Positive_regulation (induction) of RP
7) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Regulation of the threshold for RP induction by PDE1
Positive_regulation (induction) of RP
8) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Using the simulation model, we next attempted to address how the threshold for RP induction is determined.
Positive_regulation (induction) of RP
9) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The limited influence of calcineurin activity on the Ca2+ threshold for RP induction is presumably attributable to its shorter-lasting effect on PP-1 activity and the lower affinity for Ca2+/CaM compared with PDE1.
Positive_regulation (induction) of RP
10) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Although calcineurin was not significantly involved in the Ca2+ threshold for RP induction, it is critical for the GABABR-mediated suppression of RP induction (Kawaguchi and Hirano, 2002).
Positive_regulation (induction) of RP
11) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Although calcineurin was not significantly involved in the Ca2+ threshold for RP induction, it is critical for the GABABR-mediated suppression of RP induction (Kawaguchi and Hirano, 2002).
Positive_regulation (induction) of RP
12) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Next, we examined the threshold for RP induction.
Spec (examined) Positive_regulation (induction) of RP
13) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.08
Recently, we reported that mGluR1 activity supports RP induction by facilitating the PKA/phospho-DARPP-32/PP-1 inhibition pathway (Sugiyama et al, 2008).
Positive_regulation (induction) of RP
14) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.15 Pain Relevance 0.12
These pathways might regulate the [Ca2+]i threshold for RP induction.
Positive_regulation (induction) of RP
15) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
As shown in Figure 8B, conditioning stimulation consisting of shorter depolarization pulses than 500 ms failed to induce RP (500 ms, 175±21%; 100 ms, 110±18%; 60 ms, 100±13%; 40 ms, 109±2%; 20 ms, 108±17%).
Neg (failed) Positive_regulation (induce) of RP
16) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.07
It was suggested that GABABR suppresses the RP induction by reducing the amount of cAMP and the PKA activity by Gi-mediated inhibition of adenylyl cyclase (Kawaguchi and Hirano, 2000).
Positive_regulation (induction) of RP
17) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
When PDE1 was inhibited by 8-MM-IBMX, conditioning stimulation consisting of 40-ms depolarization pulses was sufficient to induce RP (500 ms, 174±7%; 100 ms, 172±28%; 60 ms, 177±2%; 40 ms, 173±15%; 20 ms, 99±6%) (Figure 8C).
Positive_regulation (induce) of RP
18) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.06
RP is heterosynaptically induced by excitatory synaptic inputs such as those from a climbing fiber (Kano et al, 1992), whereas it is suppressed by activation of a presynaptic inhibitory interneuron (Kawaguchi and Hirano, 2000).
Positive_regulation (induced) of RP in climbing fiber associated with interneuron
19) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.07 Pain Relevance 0.13
Induction of RP requires a postsynaptic [Ca2+]i increase and the subsequent activation of Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) (Kano et al, 1992, 1996).
Positive_regulation (Induction) of RP
20) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.15 Pain Relevance 0.25

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