INT138343

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.06
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
endothelial cells 5
platelet 4
bladder 2
macrophages 1
lymphocytes 1
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 55 99.82 Very High Very High Very High
Inflammatory response 8 98.76 Very High Very High Very High
cva 38 90.60 High High
ischemia 6 79.60 Quite High
anesthesia 52 75.08 Quite High
cytokine 28 66.88 Quite High
cINOD 2 56.00 Quite High
Bioavailability 3 32.56 Quite Low
Pain 8 26.52 Quite Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 99.82 Very High Very High Very High
Diabetes Mellitus 80 99.60 Very High Very High Very High
Vasculitis 12 99.36 Very High Very High Very High
Myocardial Infarction 70 98.64 Very High Very High Very High
Hyperglycemia 50 98.02 Very High Very High Very High
Hemorrhage 77 95.88 Very High Very High Very High
Injury 42 95.12 Very High Very High Very High
Coagulation Disorder 20 91.88 High High
Thrombosis 9 84.96 Quite High
Coronary Artery Disease 6 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our findings demonstrate that acute hyperglycemia in acute myocardial infarction patients without a previous history of diabetes is associated with increased thrombin generation and platelet activation at the site of vascular injury as well as greater resistance to fibrinolysis.
Positive_regulation (increased) of Localization (generation) of thrombin in platelet associated with hyperglycemia, diabetes mellitus, vasculitis and myocardial infarction
1) Confidence 0.41 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.00 Pain Relevance 0
The current study shows that elevated glucose levels are associated with significantly augmented thrombin formation and platelet protein secretion in response to vascular injury not only in patients with type 2 diabetes but also in those with no prior history of diabetes and hyperglycemia during acute myocardial infarction.
Positive_regulation (augmented) of Localization (secretion) of thrombin in platelet associated with hyperglycemia, diabetes mellitus, vasculitis and myocardial infarction
2) Confidence 0.38 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.21 Pain Relevance 0.04
RESULTS: The immediate increase in prostacyclin release from thrombin or tryptase stimulated human bladder microvascular endothelial cells depended on the activation of membrane associated calcium independent phospholipase A2, resulting in an increase in arachidonic acid production.
Positive_regulation (increase) of Localization (release) of thrombin in bladder
3) Confidence 0.18 Published 2006 Journal J. Urol. Section Body Doc Link 16952710 Disease Relevance 0 Pain Relevance 0
A dose-dependent prolongation of PT, activated partial thromboplastin time (aPTT), and HepTest to a similar extent to inhibition of FXa were seen, and it was suggested that the inhibition of the FXa activity of rivaroxaban can be monitored by these clotting tests or by measurement of FXa alone (Kubitza 2005a).
Positive_regulation (activated) of Localization (prolongation) of PT associated with coagulation disorder
4) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.44 Pain Relevance 0.06
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Positive_regulation (promotes) of Localization (release) of serine protease in endothelial cells associated with inflammation
5) Confidence 0.11 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Positive_regulation (promotes) of in neutrophils Localization (release) of serine protease in endothelial cells associated with inflammation
6) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Positive_regulation (promotes) of in macrophages Localization (release) of serine protease in endothelial cells associated with inflammation
7) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29
The inflammatory process promotes the release of serine protease by neutrophils, macrophages, lymphocytes, and endothelial cells.
Positive_regulation (promotes) of in lymphocytes Localization (release) of serine protease in endothelial cells associated with inflammation
8) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.60 Pain Relevance 0.29

General Comments

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