INT138347

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 49 100.00 Very High Very High Very High
cocaine 111 99.44 Very High Very High Very High
Eae 23 98.36 Very High Very High Very High
Nucleus accumbens 3 92.68 High High
fluoxetine 3 87.32 High High
Serotonin 2 78.60 Quite High
Neurotransmitter 2 77.40 Quite High
monoamine 3 76.72 Quite High
Nicotine 1 55.08 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 11 98.96 Very High Very High Very High
Aggression 1 60.72 Quite High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is not clear how the modulation of DAT would affect cocaine induced reward and locomotor activity.
Phosphorylation (modulation) of DAT associated with eae and cocaine
1) Confidence 0.71 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.40 Pain Relevance 0.80
Under basal conditions, dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation, activation of ERK, and inactivation of Akt as compared with wild-type littermates.
Phosphorylation (phosphorylation) of dopamine transporter associated with targeted disruption and dopamine
2) Confidence 0.20 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.62 Pain Relevance 0.47

General Comments

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