INT138348

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 1.40
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
nucleus accumbens 7
striatum 4
caudate-putamen 1
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 524 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Nucleus accumbens 120 99.68 Very High Very High Very High
Opioid 3 93.72 High High
opioid receptor 2 93.44 High High
Ventral tegmentum 74 93.32 High High
antagonist 13 92.16 High High
Eae 30 90.20 High High
cocaine 89 90.00 High High
dopamine receptor 40 80.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 18 99.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 41 97.32 Very High Very High Very High
Depression 46 51.88 Quite High
Sprains And Strains 20 5.00 Very Low Very Low Very Low
Aggression 15 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with higher levels of phosphorylation of TH, we also find increased levels of phosphorylation of DARPP-32.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of DARPP-32
1) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.33
Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of DARPP-32 in striatum
2) Confidence 0.47 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.31
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of DARPP-32 in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
Phosphorylation of DARPP-32, a marker for dopamine D1-like receptor activation, was elevated within nucleus accumbens and caudate-putamen in neglectful versus nurturing dams.


Positive_regulation (elevated) of in caudate-putamen Phosphorylation (Phosphorylation) of DARPP-32 in nucleus accumbens associated with nucleus accumbens and dopamine
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.52
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of pDARPP-32 in nucleus accumbens associated with nucleus accumbens
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
Under basal conditions, dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation, activation of ERK, and inactivation of Akt as compared with wild-type littermates.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of DARPP-32 associated with targeted disruption and dopamine
6) Confidence 0.30 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.61 Pain Relevance 0.46
Under basal conditions, dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation, activation of ERK, and inactivation of Akt as compared with wild-type littermates.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of DARPP-32 associated with targeted disruption and dopamine
7) Confidence 0.30 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.61 Pain Relevance 0.46
Reduction of PKA activity facilitates calcineurin (a Ca2+-activated protein phosphatase, also called PP2B)-mediated dephosphorylation of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa) (Kawaguchi and Hirano, 2002).
Positive_regulation (mediated) of Phosphorylation (dephosphorylation) of DARPP-32 associated with dopamine
8) Confidence 0.23 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.10 Pain Relevance 0.22
By contrast, haloperidol-induced DARPP-32 Thr34 phosphorylation was restricted to striatopallidal MSNs (Bateup et al., 2008).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of DARPP-32
9) Confidence 0.22 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.08 Pain Relevance 0.13
Calcineurin-mediated DARPP-32 dephosphorylation and PP-1 activation is a feedforward inhibitory pathway to CaMKII activation.
Positive_regulation (mediated) of Phosphorylation (dephosphorylation) of DARPP-32
10) Confidence 0.21 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Calcineurin-mediated DARPP-32 dephosphorylation and PP-1 activation is a feedforward inhibitory pathway to CaMKII activation.
Positive_regulation (activation) of Phosphorylation (dephosphorylation) of DARPP-32
11) Confidence 0.21 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Calcineurin-mediated DARPP-32 dephosphorylation and PP-1 activation is a feedforward inhibitory pathway to CaMKII activation.
Positive_regulation (activation) of Phosphorylation (dephosphorylation) of DARPP-32
12) Confidence 0.21 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Repeated transient dopamine pulses, with temporal properties consistent with reinforcement learning trials (e.g., eight brief pulses at 20-s intervals) produces an accumulation of PKAc (Figure 5A, green dashed line), and significantly increases the phosphorylation of DARPP-32 at Thr34 (Figure 5B).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of DARPP-32 associated with dopamine
13) Confidence 0.15 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.31
When DARPP-32 is phosphorylated at Thr75, it binds to and inactivates PKA [15] with an affinity of 2.7 ?
Positive_regulation (When) of Phosphorylation (phosphorylated) of DARPP-32
14) Confidence 0.15 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.06
This regulation required combined action of dopamine D1 receptors and glutamate receptors [15,16,18-20] as well as the PKA-dependent phosphorylation of DARPP-32, an important regulatory protein of D1 receptor signaling cascade in the striatum, and the inhibition of protein phosphatase-1 [16].
Positive_regulation (required) of Phosphorylation (phosphorylation) of DARPP-32 in striatum associated with dopamine and glutamate receptor
15) Confidence 0.13 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.58
Phosphorylation of DARPP-32, a marker for dopamine D1-like receptor activation, was elevated within nucleus accumbens and caudate-putamen in neglectful versus nurturing dams.


Positive_regulation (elevated) of Phosphorylation (Phosphorylation) of DARPP-32 in nucleus accumbens associated with nucleus accumbens and dopamine
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.52

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