INT138351

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.77
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
sensory neurons 2
hair cell 2
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 94 100.00 Very High Very High Very High
agonist 69 100.00 Very High Very High Very High
bradykinin 6 100.00 Very High Very High Very High
TRP channel 21 99.98 Very High Very High Very High
Inflammatory mediators 8 95.60 Very High Very High Very High
qutenza 35 90.92 High High
dorsal root ganglion 6 90.64 High High
Hyperalgesia 6 89.32 High High
allodynia 10 88.88 High High
intrathecal 5 86.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 99 100.00 Very High Very High Very High
Hypersensitivity 39 95.52 Very High Very High Very High
Ganglion Cysts 8 90.64 High High
Hyperalgesia 8 89.32 High High
Neuropathic Pain 37 88.88 High High
Targeted Disruption 6 77.68 Quite High
Inflammatory Pain 13 76.40 Quite High
Pain 29 65.20 Quite High
Nociception 27 63.92 Quite High
Arthritis 5 27.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, Obata et al. (2005) reported that antisense treatment only reduced the increased TRPA1 receptor expression following CFA injection, and thus greater receptor blockade/inactivation may be required to inhibit mechanical hypersensitivity.
Negative_regulation (reduced) of Gene_expression (expression) of TRPA1 receptor associated with hypersensitivity
1) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.91 Pain Relevance 0.34
TRP channel block of cold and TRPA1 agonist responses in cutaneous primary afferents
Negative_regulation (block) of Gene_expression (responses) of TRPA1 associated with trp channel and agonist
2) Confidence 0.42 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.18 Pain Relevance 0.47
The number of DRG neurones expressing TRPA1 increases in inflammation (these data; Obata et al., 2005) so there is evidence to support the latter mechanism.
Negative_regulation (number) of Gene_expression (expressing) of TRPA1 associated with inflammation
3) Confidence 0.42 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.73 Pain Relevance 0.58
We observed a high degree of functional co-expression of TRPM8, the receptors for the inflammatory agents bradykinin, prostaglandin E2 and histamine, and TRPA1 in cultured sensory neurones.
Negative_regulation (degree) of Gene_expression (co-expression) of TRPA1 associated with inflammation and bradykinin
4) Confidence 0.41 Published 2007 Journal Exp Brain Res Section Abstract Doc Link 17006682 Disease Relevance 0.59 Pain Relevance 0.50
These findings were based upon localization of mTRPA1 transcripts and protein in hair cells, deficits in hair cell function after inhibition of TRPA1 protein expression, and similar biophysical and pharmacological properties of heterologously expressed TRPA1 and the hair cell transduction channel.
Negative_regulation (inhibition) of Gene_expression (expression) of TRPA1 in hair cell
5) Confidence 0.33 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.03
Furthermore, knockdown of TRPA1 (transient receptor potential subtype A1) expression in sensory neurons by specific small interfering RNA abolished the WIN effect on TRPV1 dephosphorylation, suggesting that WIN acts through TRPA1.
Negative_regulation (knockdown) of Gene_expression (expression) of TRPA1 in sensory neurons
6) Confidence 0.21 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.36 Pain Relevance 0.52

General Comments

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