INT138369

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss1) extracellular space (Prss1) extracellular region (Prss1)
Prss1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 14 98.84 Very High Very High Very High
Bile 2 90.12 High High
abdominal pain 1 85.24 High High
fibrosis 1 73.52 Quite High
Pain management 1 45.12 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 16 98.84 Very High Very High Very High
Disease 2 93.56 High High
Pancreatic Cancer 3 92.52 High High
Duodenal Obstruction 2 91.32 High High
Diabetes Mellitus 2 89.36 High High
Vomiting 2 88.40 High High
Abdominal Pain 1 85.24 High High
Cystic Fibrosis 1 74.08 Quite High
Pain 1 45.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The subjects were screened for PRSS1 mutations: R122H, R122C, A16V, N29I; SPINK1 N34S variant; panel of 14 CFTR defects: INNOLiPA CFTR12, CFTRdele2,3 and IVS8-T variant or panel of 3 CFTR defects-F508del, CFTRdele2,3 and IVS8-T; AAT mutations: E264V, E342K.
Positive_regulation (screened) of PRSS1
1) Confidence 0.31 Published 2006 Journal J. Pediatr. Gastroenterol. Nutr. Section Body Doc Link 16954950 Disease Relevance 0.19 Pain Relevance 0
It has been shown that the PRSS1 mutations increase autocatalytic conversion of trypsinogen to active trypsin, and thus probably cause premature, intrapancreatic trypsinogen activation, disturbing the intrapancreatic balance of proteases and their inhibitors.
Positive_regulation (increase) of PRSS1
2) Confidence 0.09 Published 2008 Journal Best Pract Res Clin Gastroenterol Section Abstract Doc Link 18206817 Disease Relevance 1.46 Pain Relevance 0.92

General Comments

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