INT13837

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.43
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 458 100.00 Very High Very High Very High
Antinociceptive 1 99.44 Very High Very High Very High
antinociception 6 97.48 Very High Very High Very High
tail-flick 2 94.72 High High
nMDA receptor 33 88.72 High High
antagonist 29 75.00 Quite High
agonist 26 75.00 Quite High
Serotonin 66 74.72 Quite High
midbrain 63 61.88 Quite High
amygdala 12 57.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 98.78 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 489 98.42 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 33 88.20 High High
Cognitive Disorder 27 80.24 Quite High
Hypertension 21 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of the above findings, it may be concluded that D-1 receptor activation can decrease the baclofen antinociceptive effect.
Negative_regulation (decrease) of Positive_regulation (activation) of D-1 receptor associated with antinociceptive
1) Confidence 0.43 Published 1991 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1679622 Disease Relevance 0 Pain Relevance 0.80
Hyperactivity in the DAT1 knock-out mouse might be the result of increased dopamine tone or decreased phasic dopamine release with consequently impaired activation of postsynaptic DRD1 required for LTP (and LTD) to produce changes in synaptic strength necessary for associative learning and reinforcement of appropriate behaviour.
Negative_regulation (decreased) of Positive_regulation (activation) of DRD1 associated with targeted disruption, dopamine and attention deficit hyperactivity disorder
2) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.68 Pain Relevance 0.52
Weak stimuli will not cause behaviour to be reinforced in SHR because of reduced activation of the DRD1 signalling pathways.
Negative_regulation (reduced) of Positive_regulation (activation) of DRD1
3) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.08 Pain Relevance 0.17
Hyperactivity in the DAT1 knock-out mouse might be the result of increased dopamine tone or decreased phasic dopamine release with consequently impaired activation of postsynaptic DRD1 required for LTP (and LTD) to produce changes in synaptic strength necessary for associative learning and reinforcement of appropriate behaviour.
Negative_regulation (impaired) of Positive_regulation (activation) of DRD1 associated with targeted disruption, dopamine and attention deficit hyperactivity disorder
4) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.67 Pain Relevance 0.51

General Comments

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