INT13838

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 9.83
Pain Relevance 23.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
striatum 6
neurons 5
brain 2
forebrain 2
prefrontal 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 3687 100.00 Very High Very High Very High
Nucleus accumbens 345 100.00 Very High Very High Very High
agonist 189 100.00 Very High Very High Very High
dopamine receptor 72 100.00 Very High Very High Very High
cocaine 55 100.00 Very High Very High Very High
Dynorphin 44 100.00 Very High Very High Very High
Opioid 8 99.82 Very High Very High Very High
Morphine 33 99.56 Very High Very High Very High
Endogenous opioid 4 99.44 Very High Very High Very High
Substantia nigra 178 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 22 99.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2472 99.08 Very High Very High Very High
Anxiety Disorder 58 98.32 Very High Very High Very High
Targeted Disruption 139 97.56 Very High Very High Very High
Increased Venous Pressure Under Development 21 94.28 High High
Cognitive Disorder 150 93.72 High High
Muscle Rigidity 1 92.64 High High
Toxicity 17 87.40 High High
Hypertrophy 21 87.32 High High
Cv Unclassified Under Development 15 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of the above findings, it may be concluded that D-1 receptor activation can decrease the baclofen antinociceptive effect.
Positive_regulation (activation) of D-1 receptor associated with antinociceptive
1) Confidence 0.70 Published 1991 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1679622 Disease Relevance 0 Pain Relevance 0.80
Recent studies in rodent brain slice preparations have suggested that the reduction of dopaminergic transmission in the parkinsonian state results in a lack of activation of D2LRs and D1-receptors which, in turn, contributes to the development of irregular discharges in the STN (see section on STN above).
Positive_regulation (activation) of D1-receptor in brain associated with parkinson's disease
2) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.48 Pain Relevance 0.25
Additionally, this treatment with bisphenol-A produced a down-regulation of dopamine D3 receptor and an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for rewarding effects by drugs of abuse.
Positive_regulation (up-regulation) of dopamine D1 receptor in forebrain associated with dopamine
3) Confidence 0.67 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.17 Pain Relevance 0.24
Furthermore, the exposure to bisphenol-A during either organogenesis or lactation also produced an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain.
Positive_regulation (up-regulation) of dopamine D1 receptor in forebrain associated with dopamine
4) Confidence 0.67 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.24 Pain Relevance 0.26
While no changes in DA release or uptake could be detected by microdialysis, KO animals showed a significant increase in total DA tissue content in dorsal striatum, an effect accompanied by a significant increase in striatal prodynorphin and DRD1 mRNA expression levels.
Positive_regulation (increase) of DRD1 mRNA in striatum associated with dopamine
5) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.12 Pain Relevance 0.61
In addition it is possible that some weakly fluorescent drd1a-EGFP expressing neurons were overlooked.
Spec (possible) Positive_regulation (fluorescent) of drd1a in neurons
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.14 Pain Relevance 0.04
As previous studies have shown enhancement of DA neurotransmission often results in elevated dynorphin and DRD1 mRNA levels in direct striatal projecting neurons, the unbalance between the direct and indirect striatal projection pathways observed in Pten KO animals could be explained by subtle but long-term changes in DA dynamics.
Positive_regulation (results) of DRD1 mRNA in neurons associated with dopamine and dynorphin
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.11 Pain Relevance 0.55
As previous studies have shown enhancement of DA neurotransmission often results in elevated dynorphin and DRD1 mRNA levels in direct striatal projecting neurons, the unbalance between the direct and indirect striatal projection pathways observed in Pten KO animals could be explained by subtle but long-term changes in DA dynamics.
Positive_regulation (elevated) of DRD1 mRNA in neurons associated with dopamine and dynorphin
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.10 Pain Relevance 0.55
Simple compensatory up-regulation of D5 DA receptors in response to D1 receptor subtype loss does not explain our findings, because genetic inactivation of the D1 DA receptor does not alter levels of D5 DA receptor expression.
Positive_regulation (inactivation) of D1 DA receptor associated with dopamine
9) Confidence 0.40 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 12111832 Disease Relevance 0.86 Pain Relevance 0.57
Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice.
Positive_regulation (activation) of dopamine D1 receptor associated with dopamine and morphine
10) Confidence 0.39 Published 2008 Journal Neuropharmacology Section Title Doc Link 18614186 Disease Relevance 0.08 Pain Relevance 0.57
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Positive_regulation (elevated) of DRD1 in neuronal associated with dopamine receptor
11) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.44
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
Positive_regulation (elevated) of Striatal dopamine receptor D1 in neuronal associated with dopamine receptor
12) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.44
DRD1 and PDyn mRNA levels were significantly upregulated in KO animals as compared to controls (Fig. 5A and B).
Positive_regulation (upregulated) of DRD1
13) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.54
Increased DRD1 and dynorphin levels in medium spiny neurons may enhance the inhibition of DA neurons in the SNc, thereby normalizing overall DA release in the striatum.


Positive_regulation (Increased) of DRD1 in striatum associated with dopamine and dynorphin
14) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.08 Pain Relevance 0.40
Consistent with enhanced dopamine activation of DRD1 receptors being responsible for the excessively rigid serial pattern of instinctive grooming behaviour, DRD1 agonists produced similarly enhanced sequential stereotypy of syntactic grooming chains [175].
Positive_regulation (activation) of DRD1 associated with dopamine and agonist
15) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.59 Pain Relevance 0.26
Some animal models have decreased extracellular dopamine concentrations and upregulated postsynaptic dopamine D1 receptors (DRD1) while others have increased extracellular dopamine concentrations.
Positive_regulation (upregulated) of DRD1 associated with dopamine
16) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Abstract Doc Link PMC1180819 Disease Relevance 0.42 Pain Relevance 0.31
In agreement with decreased stimulus-evoked release of dopamine, postsynaptic DRD1 are increased in the caudate-putamen and nucleus accumbens of SHR [51,81,82] suggesting compensatory upregulation of postsynaptic receptors.
Positive_regulation (increased) of DRD1 in nucleus accumbens associated with nucleus accumbens and dopamine
17) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.23 Pain Relevance 0.52
Some animal models have decreased extracellular dopamine concentrations and upregulated postsynaptic dopamine D1 receptors (DRD1) while others have increased extracellular dopamine concentrations.
Positive_regulation (upregulated) of dopamine D1 associated with dopamine
18) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Abstract Doc Link PMC1180819 Disease Relevance 0.42 Pain Relevance 0.31
In conclusion, mouse ileum is under basal inhibitory control by dopamine, through D1 receptor activation, linked to adenylyl cyclase and activation of apamin-sensitive potassium channels.
Positive_regulation (activation) of D1 receptor in ileum associated with dopamine and potassium channel
19) Confidence 0.34 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 20138148 Disease Relevance 0 Pain Relevance 0.77
Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation.
Neg (independent) Positive_regulation (independent) of dopamine D-1 associated with dopamine and endogenous opioid
20) Confidence 0.33 Published 2004 Journal Neuroscience Section Title Doc Link 14960355 Disease Relevance 0.12 Pain Relevance 0.86

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