INT138426

Context Info Confidence 0.29 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.17

transport (Abcb1b, Abcg2) ATPase activity (Abcb1b, Abcg2) mitochondrion (Abcb1b) plasma membrane (Abcg2) nucleus (Abcg2) transmembrane transport (Abcb1b)

Anatomy Link Frequency livers 1 Abcb1b (Mus musculus) Abcg2 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 2 98.84 Bile 2 25.00

Disease Link Frequency Relevance Heat Targeted Disruption 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The role of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion of acetaminophen sulfate (AS) and glucuronide (AG), 4-methylumbelliferyl sulfate (4MUS) and glucuronide (4MUG), and harmol sulfate (HS) and glucuronide (HG) was studied in Abcc2(-/-), Abcg2(-/-), and Abcb1a(-/-)/Abcb1b(-/-) mouse livers perfused with the respective parent compounds using a cassette dosing approach.

P-glycoprotein Regulation (role) of Bcrp in livers associated with paracetamol

1) Confidence 0.29 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16959944 Disease Relevance 0 Pain Relevance 0.17

General Comments

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