INT138434

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 2.18
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sphk1) plasma membrane (Sphk1) nucleus (Sphk1)
DNA binding (Sphk1) kinase activity (Sphk1) cytoplasm (Sphk1)
Anatomy Link Frequency
liver 2
osteoblasts 1
renal proximal tubule 1
Sphk1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 24 99.98 Very High Very High Very High
cytokine 16 98.48 Very High Very High Very High
agonist 9 98.16 Very High Very High Very High
Inflammation 46 98.08 Very High Very High Very High
withdrawal 29 97.16 Very High Very High Very High
antagonist 16 93.72 High High
ischemia 2 92.80 High High
anesthesia 8 86.96 High High
cINOD 1 81.84 Quite High
Paracetamol 2 69.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 98.08 Very High Very High Very High
Injury 3 93.76 High High
Cv Unclassified Under Development 2 92.80 High High
Reprotox - General 1 217 92.56 High High
Apoptosis 66 91.88 High High
Renal Failure 1 84.32 Quite High
Necrosis 6 82.88 Quite High
Cancer 223 79.56 Quite High
Colitis 3 75.76 Quite High
Colon Cancer 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of dihydrotestosterone (DHT) induced a rapid and ephemeral activation of SphK1 suggestive of a non-genomic effect.
Positive_regulation (activation) of SphK1
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.37 Pain Relevance 0
The activation of SphK1 was correlated with stimulation of Akt (Fig. 6B, right panel), a pro-survival signaling pathway reported to be up-regulated during NE transdifferentiation of LNCaP induced by androgen depletion [6], [7], [23], [45].
Positive_regulation (activation) of SphK1
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
The rapid stimulation of SphK1 was dependent on activation of the PI3K/Akt signaling, which has been shown to mediate the rapid effects of androgens [39], [40].
Positive_regulation (stimulation) of SphK1
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
Under CSS conditions, the addition of dihydrotestosterone (DHT) could trigger an early and transient stimulation of SphK1 (as early as 15 min) after which SphK1 activity returned to basal levels (Fig. 4A).
Positive_regulation (stimulation) of SphK1
4) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
We next investigated the potential involvement of SphK1 in the transition to androgen refractory state after chronic androgen withdrawal.
Spec (investigated) Positive_regulation (involvement) of SphK1 associated with withdrawal
5) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.14
Of note, cAMP increase has been previously reported to be associated with activation of SphK1 in osteoblasts [47].
Positive_regulation (activation) of SphK1 in osteoblasts
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.04
The treatment with Fsk/IBMX or Epi strongly stimulated SphK1 activity (Fig. 7A), and correlated with increased cAMP content (Fig. 7B) and acquisition of NE morphology (data not shown) characterized biochemically by CgA accumulation (Fig. 7C).
Positive_regulation (stimulated) of SphK1
7) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.05
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of SPHK in liver
8) Confidence 0.46 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of sphingosine kinase in liver
9) Confidence 0.46 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
S1P is produced by the activation (i.e., phosphorylation) of sphingosine (Sph) via its 2 isoforms of sphingosine kinase-1/2 (SphK-1/2) resulting in the production of the prosurvival S1P molecule with decreasing levels of the proapoptotic Sph molecule [35].
Positive_regulation (resulting) of sphingosine kinase-1
10) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.44 Pain Relevance 0.09
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Spec (whether) Positive_regulation (stimulates) of sphingosine kinase in renal proximal tubule associated with isoflurane
11) Confidence 0.21 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.65 Pain Relevance 0.50
These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Positive_regulation (activation) of sphingosine kinase
12) Confidence 0.12 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20688834 Disease Relevance 0.72 Pain Relevance 0.22

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