INT138436

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
liver 4
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 87.20 High High
Paracetamol 2 64.40 Quite High
metalloproteinase 1 36.16 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 63 97.44 Very High Very High Very High
Death 5 96.16 Very High Very High Very High
Hepatotoxicity 2 95.76 Very High Very High Very High
INFLAMMATION 5 86.84 High High
Stress 19 50.00 Quite Low
Toxicity 8 5.00 Very Low Very Low Very Low
Osteogenesis Imperfecta 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of Gene_expression (metabolism) of SMase in liver
1) Confidence 0.41 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of Gene_expression (metabolism) of sphingomyelinase in liver
2) Confidence 0.35 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
This is in agreement with in vitro studies, and with previous reports indicating a major role for acid SMase and the FADD-caspase pathway in TNF?
Positive_regulation (role) of Gene_expression (pathway) of SMase
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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