INT138438

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.67
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
liver 2
fibroblasts 1
brainstem 1
thalamus 1
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 86.64 High High
metalloproteinase 2 85.52 High High
Paracetamol 2 64.40 Quite High
Face pain 2 50.00 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 218 99.16 Very High Very High Very High
Stress 38 98.48 Very High Very High Very High
Apoptosis 126 97.44 Very High Very High Very High
Death 22 95.60 Very High Very High Very High
Hepatotoxicity 4 95.20 Very High Very High Very High
Neuropathic Pain 2 88.96 High High
INFLAMMATION 12 86.28 High High
Pick Disease Of The Brain 24 74.64 Quite High
Congenital Anomalies 22 67.88 Quite High
Leukemia 2 52.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PtdCho-PLC and ASMase activities were also assayed in the brainstem, thalamus, and somatosensory cortex.
Gene_expression (assayed) of ASMase in brainstem
1) Confidence 0.67 Published 2009 Journal J Orofac Pain Section Body Doc Link 19492541 Disease Relevance 0.09 Pain Relevance 0
Niemann-Pick diseases thus oppose two clearly distinct groups: acid sphingomyelinase deficiencies (due to SMPD1 mutations, including types A, B and intermediate forms,) and Niemann-Pick type C, with alterations in trafficking of endocytosed cholesterol (due to NPC1 or NPC2 mutations).
Gene_expression (mutations) of SMPD1 associated with disease
2) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.61 Pain Relevance 0
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Gene_expression (metabolism) of SMase in liver
3) Confidence 0.55 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
Niemann-Pick diseases thus oppose two clearly distinct groups: acid sphingomyelinase deficiencies (due to SMPD1 mutations, including types A, B and intermediate forms,) and Niemann-Pick type C, with alterations in trafficking of endocytosed cholesterol (due to NPC1 or NPC2 mutations).
Gene_expression (deficiencies) of acid sphingomyelinase associated with disease
4) Confidence 0.48 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.66 Pain Relevance 0
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Gene_expression (metabolism) of sphingomyelinase in liver
5) Confidence 0.48 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
This is in agreement with in vitro studies, and with previous reports indicating a major role for acid SMase and the FADD-caspase pathway in TNF?
Gene_expression (pathway) of SMase
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.60 Pain Relevance 0.04
Note that the acid SMase, which is not deficient in fro/fro fibroblasts (data not shown), is unable to compensate for the defect in nSMase2-deficient cells.
Neg (not) Gene_expression (deficient) of SMase in fibroblasts
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.62 Pain Relevance 0.04
PtdCho-PLC and ASMase activities were also assayed in the brainstem, thalamus, and somatosensory cortex.
Gene_expression (assayed) of ASMase in thalamus
8) Confidence 0.23 Published 2009 Journal J Orofac Pain Section Body Doc Link 19492541 Disease Relevance 0.09 Pain Relevance 0

General Comments

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