INT138439

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 5.93
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sphk1) plasma membrane (Sphk1) nucleus (Sphk1)
DNA binding (Sphk1) kinase activity (Sphk1) cytoplasm (Sphk1)
Anatomy Link Frequency
liver 6
null cells 4
renal proximal tubule 2
tubule 2
Sphk1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 38 99.98 Very High Very High Very High
palliative 9 98.32 Very High Very High Very High
antagonist 22 94.84 High High
Paracetamol 3 94.24 High High
ischemia 4 92.80 High High
anesthesia 11 89.20 High High
rheumatoid arthritis 130 85.60 High High
Arthritis 128 82.64 Quite High
Inflammation 86 82.24 Quite High
agonist 13 61.32 Quite High
Disease Link Frequency Relevance Heat
Recurrence 18 99.22 Very High Very High Very High
Cancer 285 98.88 Very High Very High Very High
Injury 6 98.36 Very High Very High Very High
Disease 33 97.02 Very High Very High Very High
Reprotox - General 1 279 96.20 Very High Very High Very High
Carcinoma 2 94.72 High High
Stress 9 94.56 High High
Cv Unclassified Under Development 4 92.80 High High
Metastasis 54 91.24 High High
Necrosis 12 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SphK1 activity of SphK1-overexpressing LNCaP (Fig. 3A, right panel) was increased to ?
Positive_regulation (increased) of Gene_expression (activity) of SphK1
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.54 Pain Relevance 0
The SphK1 activity of SphK1-overexpressing LNCaP (Fig. 3A, right panel) was increased to ?
Positive_regulation (increased) of Gene_expression (activity) of SphK1
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.54 Pain Relevance 0
SphK1 overexpression markedly inhibited the antiproliferative effect resulting from androgen removal.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SphK1
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.55 Pain Relevance 0
In order to determine whether the in vitro findings of the potential involvement of SphK1 in NE differentiation had any relevance to human disease, sections from a representative patient who underwent palliative transurethral resection for local recurrence under complete androgen blockade were immunostained for CgA and SphK1 expression (Fig. 8).
Positive_regulation (immunostained) of Gene_expression (expression) of SphK1 associated with disease, recurrence and palliative
4) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.34 Pain Relevance 0.13
The observed SphK1 inhibition was not relying on de novo synthesis of ceramide (data not shown), which has been previously reported to accumulate following androgen ablation in LNCaP cells [48].
Positive_regulation (following) of Gene_expression (inhibition) of SphK1
5) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.63 Pain Relevance 0
Conversely, long-term removal of androgen support in LNCaP and C4-2B cells resulted in a progressive increase in SphK1 expression and activity throughout the progression to androgen-independence state, which was characterized by the acquisition of a neuroendocrine (NE)-like cell phenotype.
Positive_regulation (increase) of Gene_expression (expression) of SphK1
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779655 Disease Relevance 0.33 Pain Relevance 0
These results emphasize other findings establishing that enforced expression of SphK1 displays a cytoprotective effect against various stimuli such as chemotherapeutics notably in prostate cancer cells [36].
Positive_regulation (enforced) of Gene_expression (expression) of SphK1 associated with reprotox - general 1
7) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.48 Pain Relevance 0
The instrumental role of SphK1 inhibition in reduced cell growth was confirmed by cell viability assays, which showed that LNCaP overexpressing SphK1 were markedly less sensitive to the effects of androgen depletion (Fig. 3B).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SphK1
8) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.36 Pain Relevance 0
In parallel, SphK1 protein expression was significantly increased (Fig. 6B, right panel).
Positive_regulation (increased) of Gene_expression (expression) of SphK1 protein
9) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.05 Pain Relevance 0
The expression and activities of SPT and SPHK1 in liver increased significantly following fumonisin B1 treatment.
Positive_regulation (increased) of Gene_expression (expression) of SPHK1 in liver
10) Confidence 0.46 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.09
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of Gene_expression (metabolism) of SPHK in liver
11) Confidence 0.46 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of Gene_expression (metabolism) of sphingosine kinase in liver
12) Confidence 0.46 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
F9 cells overexpressing SphK1 exhibited elevated DNA synthesis, whereas other S1P-accumulating cells or SPL-null cells overexpressing SphK1 did not.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SphK1 in null cells
13) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.39 Pain Relevance 0.15
SK activity as well as SK1 mRNA expression increased in both cultured human proximal tubule cells (HK-2) and mouse kidneys after exposure to isoflurane.
Positive_regulation (increased) of Gene_expression (expression) of SK1 mRNA in tubule associated with isoflurane
14) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.66 Pain Relevance 0.63
F9 cells overexpressing SphK1 exhibited elevated DNA synthesis, whereas other S1P-accumulating cells or SPL-null cells overexpressing SphK1 did not.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SphK1 in null cells
15) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.41 Pain Relevance 0.16
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Spec (whether) Positive_regulation (stimulates) of Gene_expression (synthesis) of sphingosine kinase in renal proximal tubule associated with isoflurane
16) Confidence 0.21 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.66 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox