INT138440

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.94
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
plasma 1
Spt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 91.92 High High
abdominal pain 12 85.40 High High
Neuropathic pain 1 79.68 Quite High
Bile 3 76.80 Quite High
Pain 4 75.48 Quite High
imagery 3 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 222 100.00 Very High Very High Very High
Targeted Disruption 2 99.42 Very High Very High Very High
Pancreatic Cyst 6 99.20 Very High Very High Very High
Malignant Neoplastic Disease 27 98.12 Very High Very High Very High
Pancreatic Cancer 27 97.72 Very High Very High Very High
Neuropathic Pain 19 96.56 Very High Very High Very High
Metastasis 45 94.40 High High
Calcification 9 92.72 High High
Abdominal Pain 12 85.40 High High
Skin Ulcer 2 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the preoperative diagnosis of SPT in 11 patients and pancreatic cyst, benign or malignant pancreatic tumor in the rest, pancreatic tumor resection was successfully completed.
Gene_expression (diagnosis) of SPT associated with malignant neoplastic disease, cancer, pancreatic cancer and pancreatic cyst
1) Confidence 0.47 Published 2010 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2934730 Disease Relevance 1.23 Pain Relevance 0.09
MRI indicated the diagnosis of SPT in three patients.
Gene_expression (diagnosis) of SPT associated with cancer
2) Confidence 0.47 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2934730 Disease Relevance 1.58 Pain Relevance 0.10
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Gene_expression (metabolism) of SPT in liver
3) Confidence 0.23 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
The expression and activities of SPT and SPHK1 in liver increased significantly following fumonisin B1 treatment.
Gene_expression (expression) of SPT in liver
4) Confidence 0.23 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.09
Considering the superiority of MRI in terms of correlation between radiological and clinicopathological findings in SPT, MRI was strongly proposed for the diagnosis of SPT.6,10,18 Consistently, in our study, the diagnosis of SPT suggested by MRI was ultimately confirmed pathologically.
Spec (proposed) Gene_expression (proposed) of SPT associated with cancer
5) Confidence 0.21 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2934730 Disease Relevance 1.28 Pain Relevance 0
In contrast, double transgenic mice which concomitantly co-express mutant and wildtype SPT are protected and show, in parallel, also significantly lower tissue and plasma DSB levels [6].
Gene_expression (express) of SPT in plasma associated with targeted disruption
6) Confidence 0.16 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.85 Pain Relevance 0.16

General Comments

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