INT138457

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 1.68
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
siphon 1
spinal 1
gill 1
Hbtq (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 161 98.40 Very High Very High Very High
addiction 217 96.76 Very High Very High Very High
depression 100 86.40 High High
nMDA receptor 40 85.16 High High
Peripheral nervous system 10 85.08 High High
qutenza 118 84.80 Quite High
alcohol 34 78.48 Quite High
referred pain 10 67.52 Quite High
potassium channel 3 66.96 Quite High
Hippocampus 22 65.28 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 315 90.88 High High
Calculi 60 88.28 High High
Depression 100 86.40 High High
Alcohol Withdrawal Seizures 3 78.48 Quite High
Referred Pain 10 67.52 Quite High
Pain 234 55.24 Quite High
Neuropathic Pain 53 54.60 Quite High
Hyperalgesia 80 54.04 Quite High
Urological Neuroanatomy 20 50.68 Quite High
Anxiety Disorder 167 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desensitization as generalization/transfer of habituation
Gene_expression (transfer) of habituation
1) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.14 Pain Relevance 0.21
The putative generalization/transfer of habituation is converse to the secondary sensitization in similar animal models (albeit with differing stimulus intensity or type).
Gene_expression (transfer) of habituation
2) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.08 Pain Relevance 0.16
In a recent model of tail-elicited siphon withdrawal in Aplysia [69,71], however, dishabituation is expressed in reflex pathways both ipsilateral or contralateral to the primary stimulus even though habituation and sensitization are expressed only in the pathway ipsilateral to the primary stimulus.
Gene_expression (expressed) of habituation in siphon associated with withdrawal
3) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0 Pain Relevance 0.05
Indeed, response desensitization has long lurked under the dual-process theory as the putative "generalization of habituation" [75] or "transfer of habituation" [76,77] (see Sect. 2.1.2), sometimes also called "extrinsic habituation" [37].
Gene_expression (transfer) of habituation
4) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.15 Pain Relevance 0.22
The simplest example is a primary integrator-differentiator pair in the form of a sensitization-habituation complex produced by repetitive application of a primary stimulus, as demonstrated in the classic hindlimb flexion reflex of the spinal cat or the rat acoustic startle reflex shown in the dual-process theory [9-11].
Gene_expression (produced) of habituation in spinal
5) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.14 Pain Relevance 0
Desensitization as generalization/transfer of habituation
Gene_expression (generalization) of habituation
6) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.14 Pain Relevance 0.21
In this case, the minimum ISI for producing a demonstrable habituation effect is limited by the refractory period of the gill response.
Gene_expression (producing) of habituation in gill
7) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0 Pain Relevance 0.05
Rather than mediated by an extrinsic state system as originally proposed, sensitization induced by a repetitive primary stimulus could be expressed in the primary pathway(s) as with habituation, thus evidencing primary sensitization.
Gene_expression (expressed) of habituation
8) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.27 Pain Relevance 0.27
Therefore, generalization/transfer of habituation is operationally and mechanistically analogous to secondary sensitization but with differing response polarity and activation threshold.
Gene_expression (transfer) of habituation
9) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.13 Pain Relevance 0.27
The dual-process theory defined habituation by the following stimulus-response criteria [9,10,32]: 1) exponential development with repeated stimulus applications, causing exponential decrease of response to the stimulus; 2) spontaneous recovery with a short-term memory upon cessation of stimulus; 3) successive potentiation or accumulation with repeated training sessions; 4) dependence on stimulus frequency with rate and magnitude of habituation being directly related to frequency of stimulus bouts (and inversely related to ISI); 5) dependence on stimulus intensity with rate and magnitude of habituation being inversely related to stimulus intensity; 6) dependence on stimulus quantity with spontaneous recovery of habituation becoming much slower after an excessive number of stimulus bouts; 7) cross-modal generalization or transfer of habituation to other stimuli that share common habituating elements with the primary stimulus; 8) dishabituation or trumping of habituation by a novel stimulus; and 9) habituation of dishabituation upon repeated applications of the dishabituating stimulus.
Gene_expression (transfer) of habituation associated with addiction
10) Confidence 0.02 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1578596 Disease Relevance 0.06 Pain Relevance 0.20
In females, suggestive QTL were detected on Chr 1 and 9 for Taylor I (Fig. 2a), and Chr 8 for the recent RI set (Fig. 2b).
Gene_expression (detected) of QTL
11) Confidence 0.02 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.11 Pain Relevance 0.09
The QTL detected in the full expanded RI panel have higher LOD scores than those detected in the earlier panels.
Gene_expression (detected) of QTL
12) Confidence 0.02 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.23 Pain Relevance 0
One of the fundamental applications of these data is for the detection of QTL and identification of QTL candidate genes.
Gene_expression (detection) of QTL
13) Confidence 0.02 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.22 Pain Relevance 0.12
One gene from the capsaicinoid biosynthetic pathway, BCAT, and one random fruit EST, 3A2, co-localized with QTL detected in this study on chromosomes 3 and 4.
Gene_expression (detected) of QTL
14) Confidence 0.00 Published 2006 Journal Theor. Appl. Genet. Section Abstract Doc Link 16960715 Disease Relevance 0 Pain Relevance 0.08
Six QTL controlling capsaicinoid content were detected on three chromosomes.
Gene_expression (detected) of QTL
15) Confidence 0.00 Published 2006 Journal Theor. Appl. Genet. Section Abstract Doc Link 16960715 Disease Relevance 0 Pain Relevance 0.08

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