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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (MN1) cellular_component (MN1) biological_process (MN1)
Anatomy Link Frequency
mononuclear cells 1
MN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 8 97.88 Very High Very High Very High
Inflammation 5 97.72 Very High Very High Very High
rheumatoid arthritis 6 88.88 High High
cytokine 7 72.96 Quite High
Rheumatism 1 44.44 Quite Low
alcohol 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 8 97.88 Very High Very High Very High
INFLAMMATION 5 97.72 Very High Very High Very High
Rheumatoid Arthritis 6 84.96 Quite High
Disease 3 56.32 Quite High
Asthma 57 50.00 Quite Low
Hypersensitivity 30 50.00 Quite Low
Rheumatic Diseases 1 44.44 Quite Low
Heart Rate Under Development 69 5.00 Very Low Very Low Very Low
Rhinitis 11 5.00 Very Low Very Low Very Low
Respiratory Sounds 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate the expression of membrane glucocorticoid receptors (mGCR) on peripheral blood mononuclear cells (PBMC) in patients with ankylosing spondylitis (AS).
Spec (investigate) Gene_expression (expression) of mGCR in mononuclear cells associated with spinal inflammation
1) Confidence 0.60 Published 2006 Journal J. Rheumatol. Section Abstract Doc Link 16960924 Disease Relevance 0.17 Pain Relevance 0.17
Several different mechanisms may mediate this phenomenon; among them are alterations in number, binding affinity or phosphorylation status of the GCR, polymorphic changes and/or over-expression of chaperones/ co-chaperones, increased expression of inflammatory transcription factors, the multidrug resistance pump, over-expression of the GCR beta isoform, alteration in the expression of mGCR and imbalance of 11beta-hydroxysteroid dehydrogenase type 1 & 2 activity.
Gene_expression (expression) of mGCR associated with inflammation
2) Confidence 0.09 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19822064 Disease Relevance 0.75 Pain Relevance 0.64
MnBP and MBnP produced no immunosuppression (Larsen et al. 2001a).
Neg (no) Gene_expression (produced) of MnBP
3) Confidence 0.00 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.04

General Comments

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