INT138466

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ryr2)
Anatomy Link Frequency
cardiomyocytes 2
Ryr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antiarrhythmic agent 3 88.72 High High
tolerance 2 79.76 Quite High
lidocaine 2 72.64 Quite High
ischemia 3 67.28 Quite High
Bioavailability 1 62.68 Quite High
imagery 9 57.52 Quite High
Calcium channel 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 52 99.84 Very High Very High Very High
Hypertrophy 80 98.80 Very High Very High Very High
Ventricular Tachycardia 1 97.68 Very High Very High Very High
Malignant Neoplastic Disease 1 81.68 Quite High
Cv Unclassified Under Development 8 67.28 Quite High
Apoptosis 25 56.72 Quite High
Myocardial Infarction 32 39.36 Quite Low
Lymphatic System Cancer 1 23.12 Low Low
B-cell Acute Lymphoblastic Leukemia 1 22.76 Low Low
Injury 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data provide unequivocal evidence that LCC-RyR coupling undergoes a progressive failure during hypertrophy.
Regulation (undergoes) of Gene_expression (coupling) of RyR associated with hypertrophy
1) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.75 Pain Relevance 0.07
In addition, phospholamban (PLB) and ryanodine receptor (RyR) expressions were not altered in hypoxia-reoxygenated cardiomyocytes treated with thiopental.
Neg (not) Regulation (altered) of Gene_expression (expressions) of RyR in cardiomyocytes associated with hypoxia
2) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.62 Pain Relevance 0
The abnormal expression of the ryanodine receptor type 2 (RyR2) and of FKBP12.6 is reduced by CPU80617 during its ventricular tachyarrhythmia-suppressing action.
Regulation (abnormal) of Gene_expression (expression) of ryanodine receptor type 2 associated with ventricular tachycardia
3) Confidence 0.11 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 16961724 Disease Relevance 0.25 Pain Relevance 0.32

General Comments

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