INT138467

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.36
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ryr2)
Anatomy Link Frequency
cardiomyocytes 1
neurons 1
spikes 1
Ryr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 19 99.84 Very High Very High Very High
Calcitonin gene-related peptide 1 94.88 High High
Dorsal horn neuron 5 94.24 High High
long-term potentiation 68 89.72 High High
antiarrhythmic agent 3 88.72 High High
tolerance 3 78.96 Quite High
agonist 10 76.96 Quite High
imagery 24 73.60 Quite High
lidocaine 3 72.28 Quite High
ischemia 3 66.92 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 19 99.84 Very High Very High Very High
Hypoxia 52 99.16 Very High Very High Very High
Hypertrophy 160 98.40 Very High Very High Very High
Ventricular Tachycardia 1 97.68 Very High Very High Very High
Myocardial Infarction 59 84.00 Quite High
Malignant Neoplastic Disease 1 81.68 Quite High
Cv Unclassified Under Development 13 66.92 Quite High
Apoptosis 25 55.36 Quite High
Coronary Heart Disease 7 54.64 Quite High
Nociception 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig.6, RyR1 and RyR3, but not RyR2, were expressed in DRG neurons.
Gene_expression (expressed) of RyR2 in neurons associated with dorsal root ganglion
1) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.41 Pain Relevance 0.59
This finding is backed up by several independent lines of evidence, including (1) decreased chance of hit, (2) increased chance of miss, (3) the prolonged latency of LCC-RyR coupling, and (4) the prolonged delay and progressive temporal dispersion of cell-wide Ca2+ spikes.
Gene_expression (coupling) of RyR in spikes
2) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.34 Pain Relevance 0
Taken together, our data provide unequivocal evidence that LCC-RyR coupling undergoes a progressive failure during hypertrophy.
Gene_expression (coupling) of RyR associated with hypertrophy
3) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.75 Pain Relevance 0.07
In addition, phospholamban (PLB) and ryanodine receptor (RyR) expressions were not altered in hypoxia-reoxygenated cardiomyocytes treated with thiopental.
Gene_expression (expressions) of RyR in cardiomyocytes associated with hypoxia
4) Confidence 0.34 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.62 Pain Relevance 0
The abnormal expression of the ryanodine receptor type 2 (RyR2) and of FKBP12.6 is reduced by CPU80617 during its ventricular tachyarrhythmia-suppressing action.
Gene_expression (expression) of ryanodine receptor type 2 associated with ventricular tachycardia
5) Confidence 0.32 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 16961724 Disease Relevance 0.25 Pain Relevance 0.32

General Comments

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