INT138490

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.42
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
blood 2
lymphocyte 1
germline 1
Il13 (Rattus norvegicus)
Il13 - R130Q (1)
Pain Link Frequency Relevance Heat
cytokine 59 100.00 Very High Very High Very High
Hyperalgesia 3 99.08 Very High Very High Very High
Inflammation 60 94.32 High High
Paracetamol 4 94.00 High High
Pain 7 89.44 High High
Inflammatory mediators 4 80.24 Quite High
c fibre 3 32.32 Quite Low
qutenza 4 24.08 Low Low
substance P 35 5.00 Very Low Very Low Very Low
Neuropeptide 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 12 99.80 Very High Very High Very High
Hyperalgesia 3 99.08 Very High Very High Very High
Systemic Sclerosis 30 98.80 Very High Very High Very High
Hypersensitivity 15 98.66 Very High Very High Very High
Chronic Fatigue Syndrome 6 95.12 Very High Very High Very High
INFLAMMATION 58 94.32 High High
Injury 12 93.28 High High
Cv General 3 Under Development 2 92.24 High High
Pain 5 89.44 High High
Fatigue 1 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.
Positive_regulation (increases) of interleukin-13 associated with hyperalgesia and infection
1) Confidence 0.36 Published 2009 Journal Exp. Parasitol. Section Title Doc Link 19061890 Disease Relevance 0.77 Pain Relevance 0.54
Blood samples were taken before and 48 h after PCI to evaluate serum IL-4 and IL-13 levels.
Positive_regulation (evaluate) of IL-13 in Blood
2) Confidence 0.14 Published 2008 Journal Coron. Artery Dis. Section Body Doc Link 18418228 Disease Relevance 0.09 Pain Relevance 0
For the IL-13 R130Q polymorphism, the frequency of heterozygotes (RQ) as well as homozygotes for the mutation (QQ) was significantly higher in cases compared with controls, (0.40 vs 0.28 for RQ and 0.09 vs 0.02 for QQ; P = 0.030).
Positive_regulation (higher) of IL-13 (R130Q)
3) Confidence 0.12 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570578 Disease Relevance 0.85 Pain Relevance 0
Anti-inflammatory IL-13 levels were elevated (P=0.03), and cytokines important in the recruitment of monocytes, Fraktalkine (P=0.04) and macrophage inflammatory protein-1beta (P=0.009), were significantly lower in the blood of women with AD compared with controls.
Positive_regulation (elevated) of IL-13 in blood
4) Confidence 0.05 Published 2009 Journal Int J Obes (Lond) Section Body Doc Link 19621017 Disease Relevance 0.05 Pain Relevance 0
In subgroups based on SF at 48 h, high SF patients (n=11) increased in IL-1beta, IL-12, IL-6, IL-8, IL-10, and IL-13 (p<.05) 8 h post-ex.
Positive_regulation (increased) of IL-13
5) Confidence 0.04 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.59 Pain Relevance 0.31
In the late-phase allergic response, cytokines such as interleukin (IL)-4, IL-5, IL-6, IL-8, IL-13, and TNF are induced and secreted [30].
Positive_regulation (induced) of IL-13 associated with hypersensitivity and cytokine
6) Confidence 0.02 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.67 Pain Relevance 0.25
This process involves the rearrangement of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and CD40 activation [41].
Positive_regulation (activation) of IL-13 in germline associated with cytokine
7) Confidence 0.02 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 0.75 Pain Relevance 0.19
IL-6 levels continued to fall from days 2 to 3 (p<0.05), whereas increased levels were found for several cytokines (IL-12, IL-13, IL-18 and IL-1beta) (p<0.05).
Positive_regulation (increased) of IL-13 associated with cytokine
8) Confidence 0.01 Published 2006 Journal Acta Trop. Section Abstract Doc Link 16962547 Disease Relevance 0.49 Pain Relevance 0.72
SSc has been associated with T helper lymphocyte type-2 (TH-2) activation, cytokine production (particularly Il-4, IL-13, and IL-17), and excess collagen accumulation, which could participate in the development of vasculopathy [7].
Positive_regulation (activation) of IL-13 in lymphocyte associated with systemic sclerosis and cytokine
9) Confidence 0.01 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 1.16 Pain Relevance 0.05

General Comments

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