INT138543

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.10
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
lymphocyte 2
cytotoxic T-lymphocyte 1
Cd28 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abatacept 10 98.72 Very High Very High Very High
rheumatoid arthritis 3 94.20 High High
psoriasis 1 59.92 Quite High
Inflammation 46 36.80 Quite Low
Inflammatory response 20 35.04 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 1 99.36 Very High Very High Very High
Autoimmune Disease 5 98.32 Very High Very High Very High
Disease 15 97.80 Very High Very High Very High
Rheumatoid Arthritis 3 94.20 High High
Communicable Diseases 38 92.72 High High
Infection 20 92.00 High High
Cancer 10 82.00 Quite High
Necrosis 6 81.52 Quite High
Convalescence 34 69.60 Quite High
Acute-phase Reaction 18 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although both inhibit the CD28 costimulatory pathway, they are tailored for specific disease states--abatacept for autoimmune diseases and belatacept for transplantation.
Negative_regulation (inhibit) of CD28 associated with autoimmune disease, abatacept and disease
1) Confidence 0.11 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18269922 Disease Relevance 0.55 Pain Relevance 0.30
The decrease of the mRNA level of CD28, CD69 or LCK might be also linked in part to the decrease of the number of lymphocytes.
Negative_regulation (decrease) of CD28 in lymphocytes
2) Confidence 0.08 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.33 Pain Relevance 0
Abatacept is a fusion protein of the cytotoxic T-lymphocyte antigen (CTLA) molecule and immunoglobulin (Ig) G1 that blocks CD28.
Negative_regulation (blocks) of CD28 in cytotoxic T-lymphocyte associated with abatacept
3) Confidence 0.07 Published 2006 Journal J Dermatolog Treat Section Abstract Doc Link 16971318 Disease Relevance 0.48 Pain Relevance 0.71
However, the decrease of lymphocyte number was less marked than the large decrease of transcript levels of CD28, CD69 and LCK.
Negative_regulation (decrease) of CD28 in lymphocyte
4) Confidence 0.06 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.73 Pain Relevance 0

General Comments

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