INT138544

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cd86)
Anatomy Link Frequency
CD86 1
T cells 1
Cd86 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abatacept 7 99.98 Very High Very High Very High
rheumatoid arthritis 2 92.72 High High
psoriasis 1 63.92 Quite High
chemokine 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 97.72 Very High Very High Very High
Rheumatoid Arthritis 2 92.72 High High
Cancer 3 86.00 High High
Necrosis 3 85.52 High High
Disease 8 82.80 Quite High
Autoimmune Disease 15 32.28 Quite Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Diabetes Mellitus-type I 7 5.00 Very Low Very Low Very Low
Renal Disease 5 5.00 Very Low Very Low Very Low
Hyperglycemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mouse model of T1D, susceptibility was associated with a variation in ctla4 gene splicing with reduced production of a spliced form lacking the CD80/CD86 ligand-binding domain [2].
Negative_regulation (lacking) of CD86 in CD86 associated with diabetes mellitus
1) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.37 Pain Relevance 0
Specifically, abatacept blocks the CD80 and CD86 ligands on the surface of antigen-presenting cells that must interface with the T-cell's CD28 receptor to activate T cells.
Negative_regulation (blocks) of CD86 in T cells associated with abatacept
2) Confidence 0.08 Published 2006 Journal J Dermatolog Treat Section Abstract Doc Link 16971318 Disease Relevance 0.50 Pain Relevance 0.72

General Comments

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