INT138560

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
RGD1565506 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 34 99.88 Very High Very High Very High
Peripheral nerve injury 3 99.68 Very High Very High Very High
qutenza 8 99.64 Very High Very High Very High
Neuropathic pain 45 97.88 Very High Very High Very High
Stimulus evoked pain 1 97.64 Very High Very High Very High
Pain 23 97.00 Very High Very High Very High
Spinal cord 17 96.88 Very High Very High Very High
dorsal root ganglion 26 93.36 High High
Inflammation 22 90.64 High High
allodynia 9 89.72 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 68 99.88 Very High Very High Very High
Neuropathic Pain 59 97.88 Very High Very High Very High
Pain 27 97.64 Very High Very High Very High
Hypersensitivity 8 97.44 Very High Very High Very High
Ganglion Cysts 28 93.36 High High
INFLAMMATION 25 90.64 High High
Nociception 13 82.24 Quite High
Hyperalgesia 25 81.76 Quite High
Inflammatory Pain 2 73.76 Quite High
Urological Neuroanatomy 4 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK is activated by calcium influx and membrane depolarization via the mitogen-activated protein kinase/extracellular signal-related protein kinase kinase (MEK).
Positive_regulation (activated) of extracellular signal-related protein kinase
1) Confidence 0.31 Published 2006 Journal Neuroscience Section Abstract Doc Link 16973292 Disease Relevance 0.35 Pain Relevance 0.81
An increase in spinal extracellular signal-related kinase (ERK) activity has been implicated in the induction and/or maintenance of pain states following noxious stimulation of the periphery [14-16].
Positive_regulation (increase) of extracellular signal-related kinase in spinal associated with pain
2) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.00 Pain Relevance 1.25
Activation of mitogen-activated protein kinases, including extracellular signal-related kinase and p38, contribute to the development and maintenance of pain hypersensitivity through transcription-dependent and transcription-independent pathways [32-34].
Positive_regulation (Activation) of extracellular signal-related kinase associated with hypersensitivity and stimulus evoked pain
3) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.28 Pain Relevance 1.18

General Comments

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