INT13857

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 2.48
Pain Relevance 5.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
liver 2
projection neurons 2
monocytes 1
lymphocytes 1
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 246 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
agonist 40 99.98 Very High Very High Very High
Glutamate 5 99.90 Very High Very High Very High
Dopamine 39 99.82 Very High Very High Very High
dopamine receptor 3 99.80 Very High Very High Very High
adenocard 8 98.64 Very High Very High Very High
projection neuron 2 98.16 Very High Very High Very High
opioid receptor 3 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 99.54 Very High Very High Very High
Sarcoidosis 3 99.42 Very High Very High Very High
Targeted Disruption 13 97.08 Very High Very High Very High
Cancer 99 96.28 Very High Very High Very High
Adenoma 59 96.26 Very High Very High Very High
Granuloma 6 94.76 High High
Granulomatous Inflammation 3 92.96 High High
Cerebellar Diseases 2 83.92 Quite High
Convulsion 1 83.84 Quite High
Acromegaly 162 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in glutamate and somatostatin binding could contribute to the enhanced excitability in the-mu-opioid receptor knockout mice.
somatostatin Binding (binding) of associated with targeted disruption, glutamate, somatostatin and opioid receptor
1) Confidence 0.24 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14963640 Disease Relevance 0.34 Pain Relevance 0.56
Although the most important effect of somatostatin analogs is the inhibition of GH secretion by the adenoma leading to a subsequent decrease in circulating liver-derived IGF-I, part of the peripheral effects of these analogs is caused by the direct inhibition of IGF-I gene transcription after binding to the somatostatin receptor (Serri et al 1992; Murray et al 2004).
somatostatin Binding (binding) of in liver associated with adenoma and somatostatin
2) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.41 Pain Relevance 0.29
In RMN, both preproenkephalin mRNA and preprotachykinin mRNA increased significantly in the striatum, with unaltered GAD mRNA, [(3)H]spiperone binding, [(3)H]QNB binding and preprosomatostatin mRNA, thus indicating the dysfunction of striatal projection neurons.
preprosomatostatin mRNA Binding (binding) of in projection neurons associated with generalized anxiety disorder and projection neuron
3) Confidence 0.18 Published 1996 Journal Brain Res. Section Abstract Doc Link 8861630 Disease Relevance 0.18 Pain Relevance 0.05
After binding of somatostatin to its receptor, the activities of adenyl cyclase and of calcium channels are inhibited, whereas phosphotyrosine phosphatase activity and mitogen-activated protein kinases activity are stimulated.
somatostatin Binding (binding) of associated with calcium channel and somatostatin
4) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.20 Pain Relevance 0.51
This class of drugs combines dopamine and somatostatin structural elements and retains affinity for specific somatostatin and dopamine receptor subtypes.
somatostatin Binding (affinity) of associated with dopamine, dopamine receptor and somatostatin
5) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.15 Pain Relevance 0.45
In RMN, both preproenkephalin mRNA and preprotachykinin mRNA increased significantly in the striatum, with unaltered GAD mRNA, [(3)H]spiperone binding, [(3)H]QNB binding and preprosomatostatin mRNA, thus indicating the dysfunction of striatal projection neurons.
preprosomatostatin mRNA Binding (binding) of in projection neurons associated with generalized anxiety disorder and projection neuron
6) Confidence 0.14 Published 1996 Journal Brain Res. Section Abstract Doc Link 8861630 Disease Relevance 0.18 Pain Relevance 0.05
Concomitant with the SRIF, insulin, and glucose infusions, adenosine was infused in logarithmically increasing rates (0, 0.01, 0.1, 1.0, 10 or 100 mumol/min) for 30 minutes each into the main left coronary arteries.
SRIF Binding (Concomitant) of associated with adenocard and somatostatin
7) Confidence 0.09 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1680214 Disease Relevance 0 Pain Relevance 0.44
The presence of binding sites for somatostatin and the expression of mRNA for somatostatin receptors (sstr1-5) on lymphocytes and monocytes is established, although the expression of a particular somatostatin receptor subtype on T lymphocytes seems to vary with species and with the origins of the T cells.
somatostatin Binding (binding) of in monocytes associated with somatostatin
8) Confidence 0.09 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.09 Pain Relevance 0.54
Similarly, granulomata of sarcoidosis patients have been known to bind the somatostatin receptor ligand octreotide in vivo [39].
somatostatin Binding (bind) of associated with sarcoidosis and somatostatin
9) Confidence 0.09 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.32 Pain Relevance 0.54
Although the most important effect of somatostatin analogs is the inhibition of tumor-derived GH and the subsequent fall in circulating liver-derived IGF-I, part of the peripheral effects are caused by a direct inhibition of IGF-I gene transcription via activation after binding to the somatostatin receptor (Serri et al 1992; Le Roith et al 2001; Murray et al 2004).
somatostatin Binding (binding) of in liver associated with cancer and somatostatin
10) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.47
Therefore it is not surprising that the addition of the dopamine agonist cabergoline to chronic somatostatin analog treatment in patients who fail to normalize GH secretion under monotherapy is still able to decrease serum IGF-I concentrations into the normal range in 30%–40% of patients, irrespective of the prolactin concentration (Cozzi et al 2004).
somatostatin Neg (not) Binding (cabergoline) of associated with dopamine, somatostatin and agonist
11) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.33 Pain Relevance 0.75
The presence of binding sites for somatostatin and the expression of mRNA for somatostatin receptors (sstr1-5) on lymphocytes and monocytes is established, although the expression of a particular somatostatin receptor subtype on T lymphocytes seems to vary with species and with the origins of the T cells.
somatostatin Binding (binding) of in lymphocytes associated with somatostatin
12) Confidence 0.03 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.09 Pain Relevance 0.54
Alteration of pulsatile growth hormone secretion by growth-inducing exercise: involvement of endogenous opiates and somatostatin.
somatostatin Binding (Alteration) of associated with narcan, somatostatin and opiate
13) Confidence 0.02 Published 1986 Journal Endocrinology Section Title Doc Link 2867892 Disease Relevance 0 Pain Relevance 0.59

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