INT138580

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry13) endoplasmic reticulum (P2ry13) plasma membrane (P2ry13)
signal transducer activity (P2ry13)
Anatomy Link Frequency
sensory neurons 1
P2ry13 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 97.28 Very High Very High Very High
Action potential 4 97.16 Very High Very High Very High
agonist 37 96.64 Very High Very High Very High
Neuropeptide 4 95.56 Very High Very High Very High
imagery 18 94.64 High High
nociceptor 34 87.08 High High
adenocard 6 75.36 Quite High
Analgesic 4 74.08 Quite High
Eae 6 50.00 Quite Low
Inflammation 32 36.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 62 82.48 Quite High
Inflammatory Pain 4 50.00 Quite Low
Injury 14 36.28 Quite Low
INFLAMMATION 32 36.00 Quite Low
Hyperalgesia 32 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Bordatella Infection 6 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Hypoalagesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both P2Y12 and P2Y13 are activated by ADP [16], but, P2Y13 is the only P2Y receptor with high affinity for IDP.
Positive_regulation (activated) of P2Y13
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0 Pain Relevance 0.33
In sensory neurons, activation of the Gq-coupled receptor P2Y2 by ATP and/or UTP causes the release of intracellular calcium stores, action potential firing, the release of neuropeptides and activation of the transcription factor CREB ([4-6]).
Positive_regulation (activation) of Gq-coupled receptor P2Y2 in sensory neurons associated with action potential and neuropeptide
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0.23 Pain Relevance 0.36
This suggested involvement of P2Y purinergic receptors (P2YR), because P2YRs induce Ca(2+) release from intracellular stores, whereas P2XRs are Ca(2+)-permeable ion channels.
Positive_regulation (involvement) of P2YR
3) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16973929 Disease Relevance 0 Pain Relevance 0.03

General Comments

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