INT138601

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L2) peptidase activity (F2) extracellular space (F2)
mitochondrion (BCL2L2) extracellular region (F2) plasma membrane (F2)
BCL2L2 (Homo sapiens)
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 97.12 Very High Very High Very High
Leflunomide 8 96.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1 99.40 Very High Very High Very High
Injury 5 86.92 High High
Death 3 83.68 Quite High
Stress 1 56.24 Quite High
Disease 1 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, we demonstrate that leflunomide (20 microM) inhibited the APAP-induced early (3 h) activation (phosphorylation) of JNK1/2, thus inhibiting phosphorylation of the anti-apoptotic protein Bcl-2 and preventing P-Bcl-2-mediated induction of the mPT.
P-Bcl-2-mediated Positive_regulation (induction) of mPT associated with paracetamol, leflunomide and apoptosis
1) Confidence 0.00 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16979204 Disease Relevance 0.66 Pain Relevance 0.91

General Comments

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