INT13861

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Context Info
Confidence 0.10
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.08
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
hypothalamus 4
brain 2
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 18 99.62 Very High Very High Very High
narcan 17 99.52 Very High Very High Very High
Neurotransmitter 2 99.20 Very High Very High Very High
Dynorphin 3 94.32 High High
Potency 1 80.56 Quite High
Opioid 5 75.00 Quite High
Dopamine 2 31.36 Quite Low
Disease Link Frequency Relevance Heat
Decapitation 1 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanisms of melatonin inhibition of neurohypophysial hormone release from the rat hypothalamus in vitro.
Negative_regulation (inhibition) of Localization (release) of neurohypophysial hormone in hypothalamus associated with narcan
1) Confidence 0.10 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.62
The effect of neurotransmitter receptor antagonists on the inhibitory effect of melatonin on neurohypophysial hormone release from the rat hypothalamus in vitro was therefore determined.
Negative_regulation (effect) of Localization (release) of neurohypophysial hormone in hypothalamus associated with neurotransmitter and antagonist
2) Confidence 0.07 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9434202 Disease Relevance 0 Pain Relevance 0.51
The data indicate that the sites of inhibition of neurohypophysial hormone release due to beta-endorphin-(1-31) are more likely to be located mostly within the blood-brain barrier, to which methyl naloxone has less ready access, than are the sites of inhibition due to dynorphin A-(1-13).
Negative_regulation (inhibition) of Localization (release) of neurohypophysial hormone in brain associated with dynorphin and narcan
3) Confidence 0.03 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1680708 Disease Relevance 0.08 Pain Relevance 0.68

General Comments

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